Structure of PDB 7wnh Chain C Binding Site BS01

Receptor Information
>7wnh Chain C (length=313) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRR
RNRCQYCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSPPVSLISALVRAHV
DSNPAMTSLDYSRFQANPDTQHIQQFYDLLTGSMEIIRGWAEKIPGFADL
PKADQDLLFESAFLELFVLRLAYRSNPVEGKLIFCNGVVLHRLQCVRGFG
EWIDSIVEFSSNLQNMNIDISAFSCIAALAMVTERHGLKEPKRVEELQNK
IVNCLKDHVTFNNGNYLSKLLGKLPELRTLCTQGLQRIFYLKLEDLVPPP
AIIDKLFLDTLPF
Ligand information
Receptor-Ligand Complex Structure
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PDB7wnh Integrative analysis reveals structural basis for transcription activation of Nurr1 and Nurr1-RXR alpha heterodimer.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		C272 Q273 H274 Y275 K284 V332 V333 R334 G340 R342 G343 R344
Binding residue
(residue number reindexed from 1)		C11 Q12 H13 Y14 K23 V71 V72 R73 G79 R81 G82 R83
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0004879 nuclear receptor activity
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7wnh, PDBe:7wnh, PDBj:7wnh
PDBsum7wnh
PubMed36442107
UniProtP43354|NR4A2_HUMAN Nuclear receptor subfamily 4 group A member 2 (Gene Name=NR4A2)

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