Structure of PDB 7whu Chain C Binding Site BS01

Receptor Information
>7whu Chain C (length=218) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRA
VRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATI
NANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTS
LCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYP
DAFAPVAQFVNWIDSIIQ
Ligand information
Receptor-Ligand Complex Structure
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PDB7whu Sequence preference and scaffolding requirement for the inhibition of human neutrophil elastase by ecotin peptide
Resolution2.89 Å
Binding residue
(original residue number in PDB)		V176 F178 S181 A195 S196 F197 V198 R199A
Binding residue
(residue number reindexed from 1)		V168 F170 S173 A187 S188 F189 V190 R191
Enzymatic activity
Enzyme Commision number 3.4.21.37: leukocyte elastase.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:7whu, PDBe:7whu, PDBj:7whu
PDBsum7whu
PubMed
UniProtP08246|ELNE_HUMAN Neutrophil elastase (Gene Name=ELANE)

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