Structure of PDB 7w6j Chain C Binding Site BS01

Receptor Information
>7w6j Chain C (length=158) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGIV
IRSILTDKREKYYDSKGIGSSYMFRIDDSEVVDATMHGNAARFINHSCEP
NCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGA
KKCRKFLN
Ligand information
>7w6j Chain F (length=20) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
DFKELDENVEYEERESEFDI
Receptor-Ligand Complex Structure
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PDB7w6j Structural basis for product specificities of MLL family methyltransferases.
Resolution2.68 Å
Binding residue
(original residue number in PDB)		K3824 A3859 G3860 I3861 V3862 R3864 L3867 R3871 M3898 H3899 G3900 R3904
Binding residue
(residue number reindexed from 1)		K12 A47 G48 I49 V50 R52 L55 R59 M86 H87 G88 R92
Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.364: [histone H3]-lysine(4) N-methyltransferase.
External links
PDB RCSB:7w6j, PDBe:7w6j, PDBj:7w6j
PDBsum7w6j
PubMed36108631
UniProtQ03164|KMT2A_HUMAN Histone-lysine N-methyltransferase 2A (Gene Name=KMT2A)

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