Structure of PDB 7w6a Chain C Binding Site BS01
Receptor Information
>7w6a Chain C (length=159) Species:
9606
(Homo sapiens) [
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SDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGI
VIRSILTDKREKYYDSKGIGSSYMFRIDDSEVVDATMHGNAARFINHSCE
PNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCG
AKKCRKFLN
Ligand information
>7w6a Chain F (length=19) Species:
9606
(Homo sapiens) [
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FKELDENVEYEERESEFDI
Receptor-Ligand Complex Structure
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PDB
7w6a
Structural basis for product specificities of MLL family methyltransferases.
Resolution
2.21 Å
Binding residue
(original residue number in PDB)
R3821 K3824 E3857 A3859 G3860 I3861 V3862 R3864 I3866 L3867 K3870 R3871 M3898 H3899 G3900 N3901 Q3924
Binding residue
(residue number reindexed from 1)
R10 K13 E46 A48 G49 I50 V51 R53 I55 L56 K59 R60 M87 H88 G89 N90 Q113
Enzymatic activity
Enzyme Commision number
2.1.1.-
2.1.1.364
: [histone H3]-lysine(4) N-methyltransferase.
External links
PDB
RCSB:7w6a
,
PDBe:7w6a
,
PDBj:7w6a
PDBsum
7w6a
PubMed
36108631
UniProt
Q03164
|KMT2A_HUMAN Histone-lysine N-methyltransferase 2A (Gene Name=KMT2A)
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