Structure of PDB 7w67 Chain C Binding Site BS01
Receptor Information
>7w67 Chain C (length=157) Species:
9606
(Homo sapiens) [
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LPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGIVI
RSILTDKREKYYDSKGIGSSYMFRIDDSEVVDATMHGNAARFINHSCEPN
CYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAK
KCRKFLN
Ligand information
>7w67 Chain F (length=19) Species:
9606
(Homo sapiens) [
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FKELDENVEYEERESEFDI
Receptor-Ligand Complex Structure
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PDB
7w67
Structural basis for product specificities of MLL family methyltransferases.
Resolution
2.194 Å
Binding residue
(original residue number in PDB)
R3821 K3824 E3857 A3859 G3860 I3861 V3862 R3864 L3867 K3870 R3871 M3898 H3899 G3900 R3904
Binding residue
(residue number reindexed from 1)
R8 K11 E44 A46 G47 I48 V49 R51 L54 K57 R58 M85 H86 G87 R91
Enzymatic activity
Enzyme Commision number
2.1.1.-
2.1.1.364
: [histone H3]-lysine(4) N-methyltransferase.
External links
PDB
RCSB:7w67
,
PDBe:7w67
,
PDBj:7w67
PDBsum
7w67
PubMed
36108631
UniProt
Q03164
|KMT2A_HUMAN Histone-lysine N-methyltransferase 2A (Gene Name=KMT2A)
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