Structure of PDB 7vh4 Chain C Binding Site BS01

Receptor Information

>7vh4 Chain C (length=175) Species: 83333 (Escherichia coli K-12)

ANENNLIWIDLEMTGLDPERDRIIEIATLVTDANLNILAEGPTIAVHQSD
EQLALMDDWNVRTHTASGLVERVKASTMGDREAELATLEFLKQWVPAGKS
PICGNSIGQDRRFLFKYMPELEAYFHYRYLDVSTLKELARRWKPEILDGF
TKQAMDDIRESVAELAYYREHFIKL

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 7vh4 Chain C Residue 203

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7vh4 Three-dimensional structure of a mycobacterial oligoribonuclease reveals a unique C-terminal tail that stabilizes the homodimer.
• Resolution: 2.3 Å
• Binding residue (original residue number in PDB): D12 E14
• Binding residue (residue number reindexed from 1): D10 E12
• Annotation score: 4

Enzymatic activity

• Enzyme Commision number: 3.1.15.-

Gene Ontology

Molecular Function

• GO:0000175 3'-5'-RNA exonuclease activity
• GO:0003676 nucleic acid binding
• GO:0004527 exonuclease activity
• GO:0008310 single-stranded DNA 3'-5' DNA exonuclease activity
• GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters
• GO:0034611 oligoribonucleotidase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006259 DNA metabolic process
• GO:0006401 RNA catabolic process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:7vh4, PDBe:7vh4, PDBj:7vh4
• PDBsum: 7vh4
• PubMed: 36244449
• UniProt: P0A784|ORN_ECOLI Oligoribonuclease (Gene Name=orn)