Structure of PDB 7unv Chain C Binding Site BS01 |
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| >7unv Chain A (length=2884)
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ggucaagugaagaagcgcauacgguggaugccuuggcagucagaggcgau
gaaagacgugguagccugcgaaaagcuucggggagucggcaaacagacuu
ugauccggagaucucugaaugggggaacccaccuaggauaaccuagguau
cuuguacugaauccauaggugcaagaggcgaaccaggggaacugaaacau
cuaaguacccugaggaaaagaaaucaaccgagauucccuuaguaguggcg
agcgaacggggauuagcccuuaagcuucauugauuuuagcggaacgcucu
ggaaagugcggccauagugggugauagccccguacgcgaaaggaucuuug
aagugaaaucgaguaggacggagcacgagaaacuuugucugaacaugggg
ggaccauccuccaaggcuaaauacuacugacugaccgauagugaaccagu
accgugagggaaaggcgaaaagaaccccggagaggggagugaaauagaac
cugaaaccguaugcguacaagcagugggagccuacuuguuaggugacugc
guaccuuuuguauaaugggucagcgacuuauauucaguggcaagcuuaac
cguauaggguaggcguagcgaaagcgagucuuaauagggcguuuagucgc
uggguauagacccgaaaccgggcgaucuauccaugagcagguugaagguu
agguaacacugacuggaggaccgaacccacucccguugaaaagguagggg
augacuuguggaucggagugaaaggcuaaucaagcucggagauagcuggu
ucuccucgaaagcuauuuagguagcgccucauguaucacucuggggggua
gagcacuguuucggcuagggggucaucccgacuuaccaaaccgaugcaaa
cuccgaauacccagaagugccgagcaugggagacacacggcgggugcuaa
cguccgucgugaaaagggaaacaacccagaccgccagcuaaggucccaaa
guugugguuaagugguaaacgaugugggaaggcuuagacagcuaggaggu
uggcuuagaagcagccacccuuuaaagaaagcguaauagcucacuagucg
agucggccugcgcggaagauguaacggggcucaaaccacacaccgaagcu
gcgggugucacggugacgcgguagaggagcguucuguaagccugugaagg
ugaguugagaagcuugcuggagguaucagaagugcgaaugcugacaugag
uaacgacaaugggugugaaaaacacccacgccgaaagaccaaggguuccu
gcgcaacguuaaucgacgcaggguuagucgguuccuaaggcgaggcugaa
aagcguagucgaugggaaacagguuaauauuccuguacuucugguuacug
cgauggagggacggagaaggcuaggccagcuuggcguugguuguccaagu
uuaaggugguaggcugaaaucuuagguaaauccgggguuucaaggccgag
agcugaugacgagucgucuagaugacgaagugguugaugccaugcuucca
agaaaagcuucuaagcuucagguaaccaggaaccguaccccaaaccgaca
cagguggucggguagagaauaccaaggcgcuugagagaacucgggugaag
gaacuaggcaaaauggcaccguaacuucgggagaaggugcgccggcuagg
gugaaggauuuacuccguaagcucuggcuggucgaagauaccaggccgcu
gcgacuguuuauuaaaaacacagcacucugcaaacacgaaaguggacgua
uagggugugacgccugcccggugccggaagguuaauugaugggguuagcg
caagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaa
cgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacga
auggcguaacgauggcggcgcugucuccacccgagacucagugaaauuga
aaucgcugugaagaugcaguguauccgcggcuagacggaaagaccccgug
aaccuuuacuguagcuuugcacuggacuuugagccugcuuguguaggaua
ggugggaggcuuugaagcguggacgccaguucgcguggagccauccuuga
aauaccacccuggcaugcuugagguucuaacucugguccguaauccggau
cgaggacaguguauggugggcaguuugacuggggcggucuccuccuaaag
aguaacggaggaguacgaaggugcgcucagaccggucggaaaucggucgc
agaguauaaaggcaaaagcgcgcuugacugcgagacagacacgucgagca
gguacgaaaguaggucuuagugauccggugguucuguauggaagggccau
cgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaa
gaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacau
ccuggggcugaagccggucccaaggguauggcuguucgccauuuaaagug
guacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugc
cguggacguuugagauuugagaggggcugcuccuaguacgagaggaccgg
aguggacgaaccucugguguuccgguugucacgccaguggcauugccggg
uagcuauguucggaaaagauaaccgcugaaagcaucuaagcgggaaacuu
gccucaagaugagaucucacugggaacuugauuccccugaagggccgucg
aagacuacgacguugauaggcuggguguguaagcguugugaggcguugag
cuaaccaguacuaauugcccgugaggcuugacca |
<<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<...
...<<<<<<.[[.(((.>>>.....<<<<<<<..<<<)))..]].>>>..
...>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<
<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>
>......>>>>>.>.........<<....>>...<<<<<.....<<....
.>>....>>>>>...(((.....<<<<<<..<<<<<<.<<<...<<<.<.
.....>.>>>((......<<<.....))>>>...>>>...>>>>>>..>>
>>>>...........<<<<<<<<.........>>>>>>>>......<<<<
<..<<<<>>>>>..)))......]].>>>>>>>.]]..............
.<<....>>....]].........<<<<.....>>>>.............
.....>>>>>>>>>>>.......<<<<..<<<<<.....>>>>>..>>>>
...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<
<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>
>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<
<<......>>>>>>.....>>>...<<<.<<.<<........>>.>>>>>
....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>.
.<<<<<<....<<<<<....>>>>>.<<<<<<<<..<<<<<<<<<.....
<<<...<<<.<<<<...<<.<<.........>>..>>...>>>>.>>>..
>>.>.....>>>>>>.>>>....>>>>>>>.>...<<<<<<<<<<.....
.>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((...
..<<<<<<...........<<..<<<<<..<<<.......<<<<<.<<..
.<<<<.......>>>>...>>........<<<......>>>..>>>>>..
.>>>..>>>>>.>>...........)))......>>>>>>.>>>...>>>
>>>><<<<<<<.>>>>>>>....>>>>>><.<<<<<...<<<......<<
<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><....
..<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<
<<<...<<.....>>.>>>>>>....((<<<<<<<...<<<...<<<...
.>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<
<...<<<<....<<<<..<<<..<<<<<<<<<<<...((((...>>>>>>
<<..<<<....<<<<<<<<<<<..<<.....>>.>>>>>>>..>>>>...
.>>>...>><..<<<<<<..>>>>>>...>>>>>>...>>>...>>>.>.
.......>>>>...>>....>>>>>>>>>>>>>>>..>>.....<<....
..>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<
...............<<<<<.....<..>......>>>>><<<<<<<<<<
<<...<<<.....>>>....>>>>>>>>>>>>............<<<<<<
<<<..<<<.........>>>..<<<<<<<.....<<<....>>>......
.>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<<.<<.
...>>..>>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>
>>>>>........<...........<<<<<<.....>>>>>>.....>..
..>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>..
...<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[
[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<.<............
<<<<...<<...........<<<<....>>>>........>>........
.....>>>>...>.>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>
>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<.....
......>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>..
...<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>
>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>
>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...
<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..
<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>
>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>
>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>
>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>..>>>>>.
..>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>
.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<<<<<<<<
.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>
>...>>>>>.>>>...>>>>..>..>>>>>>>>. |
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| PDB | 7unv Compact IF2 allows initiator tRNA accommodation into the P site and gates the ribosome to elongation |
| Resolution | 2.7 Å |
Binding residue
(original residue number in PDB) | K7 P8 G12 R13 R14 F15 E35 S38 K39 S40 G42 R43 N44 N45 N46 G47 R48 I49 T50 T51 R52 H53 G56 H58 K59 Q60 H61 Y62 R63 I74 Y83 P85 R87 A97 D98 R101 K147 G149 K150 Q153 I154 A155 R156 S157 A158 Y171 L176 R177 S178 R182 H200 S201 G206 K207 A208 G209 T211 R212 W213 R217 P218 T219 V220 R221 G222 V223 M225 N226 P227 D229 H230 H232 G234 G235 E236 G237 R238 T239 S240 G242 R243 H244 P245 P248 W249 T253 K254 G255 K256 K257 T258 R259 R263 T264 R271 R272 K273 |
Binding residue
(residue number reindexed from 1) | K6 P7 G11 R12 R13 F14 E34 S37 K38 S39 G41 R42 N43 N44 N45 G46 R47 I48 T49 T50 R51 H52 G55 H57 K58 Q59 H60 Y61 R62 I73 Y82 P84 R86 A96 D97 R100 K146 G148 K149 Q152 I153 A154 R155 S156 A157 Y170 L175 R176 S177 R181 H199 S200 G205 K206 A207 G208 T210 R211 W212 R216 P217 T218 V219 R220 G221 V222 M224 N225 P226 D228 H229 H231 G233 G234 E235 G236 R237 T238 S239 G241 R242 H243 P244 P247 W248 T252 K253 G254 K255 K256 T257 R258 R262 T263 R270 R271 K272 |
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