Structure of PDB 7ugw Chain C Binding Site BS01

Receptor Information
>7ugw Chain C (length=487) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RIEPVDIEQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMFDSG
FRPDRSHAKSARSVAETMGNYHPHGDASIYDSLVRMAQPWSLRYPLVDGQ
GNFGSPGNDPPAAMRFTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEP
TVLPSRFPNLLANGSGGIAVGMATNIPPHNLRELADAVFWALENHDADEE
ETLAAVMGRVKGPDFPTAGLIVGSQGTADAYKTGRGSIRMRGVVEVEEDS
RGRTSLVITELPYQVNHDNFITSIAEQVRDGKLAGISNIEDQSSDRVGLR
IVIEIKRDAVAKVVINNLYKHTQLQTSFGANMLAIVDGVPRTLRLDQLIR
YYVDHQLDVIVRRTTYRLRKANERAHILRGLVKALDALDEVIALIRASET
VDIARAGLIELLDIDEIQAQAILDMQLRRLAALERQRIIDDLAKIEAEIA
DLEDILAKPERQRGIVRDELAEIVDRHGDDRRTRIIA
Ligand information
>7ugw Chain V (length=46) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggccctacggctgaaagccgtagggccctacggctgaaagccgtag
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7ugw Evybactin is a DNA gyrase inhibitor that selectively kills Mycobacterium tuberculosis.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		Y28 R39 K49 V51 H52 H85 H87 R98 I181 G184 M185
Binding residue
(residue number reindexed from 1)		Y15 R26 K36 V38 H39 H72 H74 R85 I168 G171 M172
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006265 DNA topological change

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7ugw, PDBe:7ugw, PDBj:7ugw
PDBsum7ugw
PubMed35996001
UniProtP9WG47|GYRA_MYCTU DNA gyrase subunit A (Gene Name=gyrA)

[Back to BioLiP]