Structure of PDB 7ugg Chain C Binding Site BS01

Receptor Information
>7ugg Chain C (length=620) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RLKKRIFAAVSEGCVEELRELLQDLQDLCRRRRGLDVPDFLMHKLTASDT
GKTCLMKALLNINPNTKEIVRILLAFAEENDILDRFINAEYTEEAYEGQT
ALNIAIERRQGDITAVLIAAGADVNAHAKGVFFNPKYQHEGFYFGETPLA
LAACTNQPEIVQLLMENEQTDITSQDSRGNNILHALVTVAEDFKTQNDFV
KRMYDMILLRSGNWELETMRNNDGLTPLQLAAKMGKAEILKYILSREIKE
KPLRSLSRKFTDWAYGPVSSSLYDLTNVDTTTDNSVLEIIVYNTNIDNRH
EMLTLEPLHTLLHTKWKKFAKYMFFLSFCFYFFYNITLTLVSYYRHPLAL
THKMSWLQLLGRMFVLIWATCISVKEGIAIFLLRPSDLQSILSDAWFHFV
FFVQAVLVILSVFLYLFAYKEYLACLVLAMALGWANMLYYTRGFQSMGMY
SVMIQKVILHDVLKFLFVYILFLLGFGVALASLIEYGSFSDAVLELFKLT
IGLGDLNIQQNSTYPILFLFLLITYVILTFVLLLNMLIALMGETVENVSK
ESERIWRLQRARTILEFEKMLPEWLRSRFRMGELCKVADEDFRLCLRINE
VKWTEWKTHVSFLNEDPGPI
Ligand information
Ligand IDN8R
InChIInChI=1S/C18H27NO2/c1-2-3-15-21-17-9-7-16(8-10-17)18(20)11-14-19-12-5-4-6-13-19/h7-10H,2-6,11-15H2,1H3
InChIKeyBZEWSEKUUPWQDQ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.385
OpenEye OEToolkits 2.0.7		CCCCOc1ccc(cc1)C(=O)CCN2CCCCC2
ACDLabs 12.01CCCCOc1ccc(cc1)C(=O)CCN1CCCCC1
FormulaC18 H27 N O2
NameDyclonine;
1-(4-butoxyphenyl)-3-(piperidin-1-yl)propan-1-one
ChEMBLCHEMBL1201217
DrugBankDB00645
ZINCZINC000001530940
PDB chain7ugg Chain B Residue 907 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7ugg Structural mechanism of TRPV3 channel inhibition by the anesthetic dyclonine.
Resolution3.16 Å
Binding residue
(original residue number in PDB)		Y594 L670
Binding residue
(residue number reindexed from 1)		Y469 L534
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005261 monoatomic cation channel activity
GO:0005262 calcium channel activity
GO:0005515 protein binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0009266 response to temperature stimulus
GO:0042636 negative regulation of hair cycle
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
GO:0090280 positive regulation of calcium ion import
Cellular Component
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0043235 receptor complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7ugg, PDBe:7ugg, PDBj:7ugg
PDBsum7ugg
PubMed35589741
UniProtQ8K424|TRPV3_MOUSE Transient receptor potential cation channel subfamily V member 3 (Gene Name=Trpv3)

[Back to BioLiP]