Structure of PDB 7tx8 Chain C Binding Site BS01

Receptor Information
>7tx8 Chain C (length=294) Species: 43151 (Anopheles darlingi) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RWTALTPEETLFIYTRCQEEHLPANNSRKTYIENWHQWKLQPNDHVTQCY
TKCVLEGLELYDGKQKKFRPGRVSSQHVAYQFLNGATADEVAKYKGAIDA
LEPASDSCEDLYMAYFPVHETFVNVTRKLYHGTVEGAARVYNSDPNLKRK
NESLFTYCEKHVYGDQNREDMCRGRRYELTGSDELRNMIECVFRGLRYIK
HGDINIDEIVRDFDHINRGDLEPRVRTILSDCRGIQPYDYYSCLINSDIR
EEFKLAFDYRDVRSADYAYIVKGNTYDAQKVIAEMNKVEKHVCG
Ligand information
Ligand IDSRO
InChIInChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
InChIKeyQZAYGJVTTNCVMB-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1cc2c(cc1O)c(c[nH]2)CCN
ACDLabs 10.04Oc1cc2c(cc1)ncc2CCN
CACTVS 3.341NCCc1c[nH]c2ccc(O)cc12
FormulaC10 H12 N2 O
NameSEROTONIN;
3-(2-AMINOETHYL)-1H-INDOL-5-OL
ChEMBLCHEMBL39
DrugBankDB08839
ZINCZINC000000057058
PDB chain7tx8 Chain C Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7tx8 Functional aspects of evolution in a cluster of salivary protein genes from mosquitoes.
Resolution2.51 Å
Binding residue
(original residue number in PDB)		F158 E162 G177 R178 M191 D261
Binding residue
(residue number reindexed from 1)		F155 E159 G174 R175 M188 D258
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005549 odorant binding
GO:0090729 toxin activity
Biological Process
GO:0035821 modulation of process of another organism
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7tx8, PDBe:7tx8, PDBj:7tx8
PDBsum7tx8
PubMed35568118
UniProtB6DDQ8|D7L2_ANODA Long form salivary protein D7L2 (Gene Name=D7L2)

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