Structure of PDB 7tjh Chain C Binding Site BS01

Receptor Information
>7tjh Chain C (length=546) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ADAQRSHYTVYPSLPHIPFVKLLSGKESEVNVEKRWELYHQLHSHFHDQV
DHIIDNIEADLKAEISDLLYSRCFNTIFLLGSDSTTKIELKDESSRYNVL
IELTPKESPNVRMMLRRSMYKLYSAADAEENDVSYDLSLVENFKRLFGKD
LAMVFNFKDVDSINFNTLDNFIILLKSAFKYDHVKISLIFNINTNLSNIE
KNLRQSTIRLLKRNYHKLDVSSNKGFKYGNQIFQSFLDTVDGKLNLSDRF
VEFILSKMANNTNHNLQLLTKMLDYSLMSYFFQNAFSVFIDPVNVDFLND
DYLKILSRCPTFMFFVEGLIKQNRGLEEFFVEFLVRENPINGHAKFVARF
LEEELNITNFNLIELYHNLLIGKLDSYLDRWSACKEYKDRLHFEPIDTIF
QELFTLDNRSGLLTQSIFPSYKSNIEDNLLSWEQVLPSLSGDLDKIMAPV
LGQLFKLYREANMTINIYDFYIAFRETLPKEEILNFIRKDPSNTKLLELA
ETPDAFDKVALILFMQAIFAFENMGLIKFQSTKSYDLVEKCVWRGI
Ligand information
>7tjh Chain G (length=41) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
tacagattttatgtttagatcttttatgcttgcttttcaaa
Receptor-Ligand Complex Structure
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PDB7tjh A mechanism of origin licensing control through autoinhibition of S. cerevisiae ORC·DNA·Cdc6.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		K134 P137 R140 M141 R144 R145
Binding residue
(residue number reindexed from 1)		K106 P109 R112 M113 R116 R117
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003688 DNA replication origin binding
GO:0005515 protein binding
Biological Process
GO:0006260 DNA replication
GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication
GO:0006270 DNA replication initiation
GO:0030466 silent mating-type cassette heterochromatin formation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005656 nuclear pre-replicative complex
GO:0005664 nuclear origin of replication recognition complex
GO:0031261 DNA replication preinitiation complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7tjh, PDBe:7tjh, PDBj:7tjh
PDBsum7tjh
PubMed35217664
UniProtP54790|ORC3_YEAST Origin recognition complex subunit 3 (Gene Name=ORC3)

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