Structure of PDB 7tfj Chain C Binding Site BS01

Receptor Information
>7tfj Chain C (length=330) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EKRSKENLPWVEKYRPETLDEVYGQNEVITTVRKFVDEGKLPHLLFYGPP
GTGKTSTIVALAREIYGKNYSNMVLELNASDDRGIDVVRNQIKDFASTRQ
IFSKGFKLIILDEADAMTNAAQNALRRVIERYTKNTRFCVLANYAHKLTP
ALLSRCTRFRFQPLPQEAIERRIANVLVHEKLKLSPNAEKALIELSNGDM
RRVLNVLQSCKATLDNPDEDEISDDVIYECCGAPRPSDLKAVLKSILEDD
WGTAHYTLNKVRSAKGLALIDLIEGIVKILEDYELQNEETRVHLLTKLAD
IEYSISKGGNDQIQGSAVIGAIKASFENET
Ligand information
Receptor-Ligand Complex Structure
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PDB7tfj Cryo-EM structures reveal that RFC recognizes both the 3'- and 5'-DNA ends to load PCNA onto gaps for DNA repair.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		G89 I90 R94
Binding residue
(residue number reindexed from 1)		G84 I85 R89
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003689 DNA clamp loader activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0000077 DNA damage checkpoint signaling
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006272 leading strand elongation
GO:0006281 DNA repair
GO:0006298 mismatch repair
GO:0007064 mitotic sister chromatid cohesion
GO:0090618 DNA clamp unloading
Cellular Component
GO:0005634 nucleus
GO:0005663 DNA replication factor C complex
GO:0005829 cytosol
GO:0031389 Rad17 RFC-like complex
GO:0031390 Ctf18 RFC-like complex
GO:0031391 Elg1 RFC-like complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7tfj, PDBe:7tfj, PDBj:7tfj
PDBsum7tfj
PubMed35829698
UniProtP38629|RFC3_YEAST Replication factor C subunit 3 (Gene Name=RFC3)

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