Structure of PDB 7t92 Chain C Binding Site BS01

Receptor Information

>7t92 Chain C (length=317) Species: 573729 (Thermothelomyces thermophilus ATCC 42464)

PYAAAPDIIRAHQKDAYFQGVLANRLSDLHRRLRGARSAHAWAAETRTFA
AALYLCLTTLLGNRTLGEEYCDLVQVEEGPLLPSLPRRAGYILTAIVLPH
LASRALPSVRSAIRKRLQSRLVLRYLLTHLTPLTSGAHFRAATLAVFYFT
GAYYELSKWVWGLRYVFTGYEVLGVLLVVQMAVRAWLHVREQLRTAFGPG
TNVDVSLDEHAFTSNNELLGGGSSQRSLGEIGAMAHTPVLKAGRARYDLG
TSDKVMGWIKGAQQRKCTLCLEELKDPAATQCGHVFCWACIGDWVREKPE
CPLCRREAMVQHILPLR

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 7t92 Chain C Residue 501

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7t92 A peroxisomal ubiquitin ligase complex forms a retrotranslocation channel.
• Resolution: 3.1 Å
• Binding residue (original residue number in PDB): C417 H419 C436
• Binding residue (residue number reindexed from 1): C282 H284 C301
• Annotation score: 4

Enzymatic activity

• Enzyme Commision number: 2.3.2.27: RING-type E3 ubiquitin transferase.

Gene Ontology

Molecular Function

• GO:0008270 zinc ion binding
• GO:0016740 transferase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0007031 peroxisome organization
• GO:0015031 protein transport
• GO:0016558 protein import into peroxisome matrix
• GO:0016562 protein import into peroxisome matrix, receptor recycling
• GO:0016567 protein ubiquitination

Cellular Component

• GO:0005777 peroxisome
• GO:0005778 peroxisomal membrane
• GO:0016020 membrane

External links

• PDB: RCSB:7t92, PDBe:7t92, PDBj:7t92
• PDBsum: 7t92
• PubMed: 35768507
• UniProt: G2Q0E2|PEX10_THET4 Peroxisome assembly protein 10 (Gene Name=PEX10)