Structure of PDB 7skl Chain C Binding Site BS01

Receptor Information
>7skl Chain C (length=301) Species: 1280 (Staphylococcus aureus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AAATGTGKGVLGDTKDININSIDGGFSLEDLTHQGKLSAYNFNDQTGQAT
LITNEDENFVKDDQRAGVDANYYAKQTYDYYKNTFGRESYDNHGSPIVSL
THVNHYGGQDNRNNAAWIGDKMIYGDGDGRTFTNLSGANDVVAHELTHGV
TQETANLEYKDQSGALNESFSDVFGYFVDDEDFLMGEDVYTPGKEGDALR
SMSNPEQFGQPSHMKDYVYTEKDNGGVHTNSGIPNKAAYNVIQAIGKSKS
EQIYYRALTEYLTSNSNFKDCKDALYQAAKDLYDEQTAEQVYEAWNEVGV
E
Ligand information
>7skl Chain F (length=28) Species: 7137 (Galleria mellonella) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
FRCNDKCYCEDGYARDVNGKCIPIKDCP
Receptor-Ligand Complex Structure
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PDB7skl Structural evidence for standard-mechanism inhibition in metallopeptidases from a complex poised to resynthesize a peptide bond.
Resolution1.6 Å
Binding residue
(original residue number in PDB)		Q317 N321 N322 H352 E353 L407 R408 H436
Binding residue
(residue number reindexed from 1)		Q109 N113 N114 H144 E145 L199 R200 H228
Enzymatic activity
Enzyme Commision number 3.4.24.29: aureolysin.
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:7skl, PDBe:7skl, PDBj:7skl
PDBsum7skl
PubMed
UniProtP81177|AURE_STAAU Zinc metalloproteinase aureolysin (Gene Name=aur)

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