Structure of PDB 7sbm Chain C Binding Site BS01

Receptor Information
>7sbm Chain C (length=399) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PLEDLLFYTIAEGQEKIPVHKFITALKSTGLRTSDPRLKECMDMLRLTLQ
TTDGVMLDKDLFKKCVQSNIVLLTQAFRRKFVIPDFMSFTSHIDELYESA
KKQSGGKVADYIAKFSPDLWGVSVCTVDGQRHSTGDTKVPFCLQSCVKPL
KYAIAVNDLGTEYVHRYVGKEPSLFLNEDDKPHNPMVNAGAIVVTSLIKQ
GVNNAEKFDYVMQFLNKMAGNEYVGFSNATFQSERESGDRNFAIGYYLKE
KKCFPEGTDMVGILDFYFQLCSIEVTCESASVMAATLANGGFCPITGERV
LSPEAVRNTLSLMHSCGMWDFSGQFAFHVGLPAKSGVAGGILLVVPNVMG
MMCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYDNLRHFAKKLDPRREG
Ligand information
Ligand IDGLN
InChIInChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1
InChIKeyZDXPYRJPNDTMRX-VKHMYHEASA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(CC(=O)N)C(C(=O)O)N
OpenEye OEToolkits 1.5.0C(CC(=O)N)[C@@H](C(=O)O)N
ACDLabs 10.04O=C(N)CCC(N)C(=O)O
CACTVS 3.341N[CH](CCC(N)=O)C(O)=O
CACTVS 3.341N[C@@H](CCC(N)=O)C(O)=O
FormulaC5 H10 N2 O3
NameGLUTAMINE
ChEMBLCHEMBL930
DrugBankDB00130
ZINCZINC000001532526
PDB chain7sbm Chain C Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7sbm High-resolution structures of mitochondrial glutaminase C tetramers indicate conformational changes upon phosphate binding.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		Q285 S286 N335 E381 Y414 W466 G483 V484
Binding residue
(residue number reindexed from 1)		Q144 S145 N188 E234 Y267 W319 G336 V337
Annotation score5
Enzymatic activity
Enzyme Commision number 3.5.1.2: glutaminase.
Gene Ontology
Molecular Function
GO:0004359 glutaminase activity
Biological Process
GO:0006541 glutamine metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7sbm, PDBe:7sbm, PDBj:7sbm
PDBsum7sbm
PubMed34999118
UniProtO94925|GLSK_HUMAN Glutaminase kidney isoform, mitochondrial (Gene Name=GLS)

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