Structure of PDB 7rfk Chain C Binding Site BS01

Receptor Information
>7rfk Chain C (length=562) Species: 272563 (Clostridioides difficile 630) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QDNFLLSKEYENSLDVDTKKASGIYYTPKIIVDYIVKKTLKNHDIIKNPY
PRILDISCGCGNFLLEVYDILYDLFEENIYELKKKYDENYWTVDNIHRHI
LNYCIYGADIDEKAISILKDSLTNDIKINLFCCDSLKKKWRYKFDYIVGN
PPYIGHKKLEKKYKKFLLEKYSEVYKDKADLYFCFYKKIIDILKQGGIGS
VITPRYFLESLSGKDLREYIKSNVNVQEIVDFLGANIFKNIGVSSCILTF
DKKKTKETYIDVFKIKNEDICINKFETLEELLKSSKFEHFNINQRLLSDE
WILVNKDDETFYNKIQEKCKYSLEDIAISFQGIITGCDKAFILSKDDVKL
NLVDDKFLKCWIKSKNINKYIVDKSEYRLIYSNDIDNENTNKRILDEIIG
LYKTKLENRRECKSGIRKWYELQWGREKLFFERKKIMYPYKSNENRFAID
YDNNFSSADVYSFFIKEEYLDKFSYEYLVGILNSSVYDKYFKITAKKMSK
NIYDYYPNKVMKIRIFRDNNYEEIENLSKQIISILLNKSIDKGKVEKLQI
KMDNLIMDSLGI
Ligand information
Receptor-Ligand Complex Structure
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PDB7rfk Repurposing epigenetic inhibitors to target the Clostridioides difficile- specific DNA adenine methyltransferase and sporulation regulator CamA.
Resolution2.05 Å
Binding residue
(original residue number in PDB)		K25 Y30 N165 Y168 H171 Y221 S227 F253 I256 G257 Q346 I431 R432 W439 R441 K456 Y476 K511 M513 S514 Y521 P522 N523
Binding residue
(residue number reindexed from 1)		K20 Y25 N150 Y153 H156 Y206 S212 F238 I241 G242 Q331 I416 R417 W424 R426 K441 Y461 K496 M498 S499 Y506 P507 N508
Enzymatic activity
Enzyme Commision number 2.1.1.72: site-specific DNA-methyltransferase (adenine-specific).
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008168 methyltransferase activity
GO:0009007 site-specific DNA-methyltransferase (adenine-specific) activity
Biological Process
GO:0006304 DNA modification
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7rfk, PDBe:7rfk, PDBj:7rfk
PDBsum7rfk
PubMed34523387
UniProtQ183J3

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