Structure of PDB 7qbv Chain C Binding Site BS01

Receptor Information

>7qbv Chain C (length=411) Species: 2214 (Methanosarcina acetivorans)

MEVVVDVGGNPGVDCKGFCKYCYFKKVKDIQPLGCKYCLPFKKGCDYCTR
SVKESYSGFKSLQMVLEETANKLYFTSGEVKKFTVSGGGDLSCYPELKSL
ITFLSQFNTPIHLGYTSGKGFSKPDDALFYIDNGVTEVSFTVFATDPALR
AEYMKDPEPEASIQVLRDFCTHCEVYGAIVLLPGINDGEVLEKTLCDLEN
MGAKGAILMRFANFQENGLILNNSPIIPGITPHTVSEFTEIVRSSAEKHP
SIRITGTPLEDPLIGSPFAIRNVPEALLKLPRVSKKATIITGQVAASRLT
EIFEALGGTVNVIPVKKDIGCLITIDDFKALDLSEVTETVFIPGRAFVHD
MEIKEALRRDGVDRIVRRGPERLSVDGEMSIGMTREEVLELEVENFTELI
GQINSLGLPLE

Ligand information

• Ligand ID: SF4
• InChI: InChI=1S/4Fe.4S
• InChIKey: LJBDFODJNLIPKO-UHFFFAOYSA-N
• SMILES:
  OpenEye OEToolkits 2.0.7: [S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
  CACTVS 3.385: S1[Fe]S[Fe]1.S2[Fe]S[Fe]2
• Formula: Fe4 S4
• Name: IRON/SULFUR CLUSTER
• PDB chain: 7qbv Chain C Residue 501

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7qbv Crystallographic snapshots of a B 12 -dependent radical SAM methyltransferase.
• Resolution: 2.701 Å
• Binding residue (original residue number in PDB): P11 G12 C15 F18 C19 C22 Y115 S117 K119
• Binding residue (residue number reindexed from 1): P11 G12 C15 F18 C19 C22 Y115 S117 K119
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.1.1.379: [methyl coenzyme M reductase]-L-arginine C-5-methyltransferase.

Gene Ontology

Molecular Function

• GO:0003824 catalytic activity
• GO:0008168 methyltransferase activity
• GO:0035244 protein-arginine C-methyltransferase activity
• GO:0046872 metal ion binding
• GO:0051536 iron-sulfur cluster binding
• GO:0051539 4 iron, 4 sulfur cluster binding

Biological Process

• GO:0032259 methylation
• GO:0043687 post-translational protein modification

External links

• PDB: RCSB:7qbv, PDBe:7qbv, PDBj:7qbv
• PDBsum: 7qbv
• PubMed: 35110733
• UniProt: Q8THG6|MCRAM_METAC [Methyl coenzyme M reductase]-L-arginine C-5-methyltransferase (Gene Name=MA_4551)