Structure of PDB 7q45 Chain C Binding Site BS01
Receptor Information
>7q45 Chain C (length=368) Species:
9606
(Homo sapiens) [
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TKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVT
VEGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRH
ATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGS
SHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVAC
GSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVC
QIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKK
IVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEG
QKITRVACGSSHSVAWTT
Ligand information
>7q45 Chain D (length=10) Species:
9606
(Homo sapiens) [
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SDDDKDEDTH
Receptor-Ligand Complex Structure
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PDB
7q45
Crystal structure of RCC1-Like domain 2 of ubiquitin ligase HERC2 in complex with DXDKDED motif of Myelin transcription factor 1
Resolution
2.1 Å
Binding residue
(original residue number in PDB)
L2966 D2968 S2978 K2979 K3002 R3161 A3214 K3231 Y3234 R3236 D3283 D3285 H3286 S3318 S3319
Binding residue
(residue number reindexed from 1)
L8 D10 S20 K21 K44 R203 A256 K273 Y276 R278 D325 D327 H328 S360 S361
Enzymatic activity
Enzyme Commision number
2.3.2.26
: HECT-type E3 ubiquitin transferase.
External links
PDB
RCSB:7q45
,
PDBe:7q45
,
PDBj:7q45
PDBsum
7q45
PubMed
UniProt
O95714
|HERC2_HUMAN E3 ubiquitin-protein ligase HERC2 (Gene Name=HERC2)
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