Structure of PDB 7os4 Chain C Binding Site BS01

Receptor Information

>7os4 Chain C (length=359) Species: 10090 (Mus musculus)

VFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKD
KIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRI
VVIPGKVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNM
FPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYF
RQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVH
GLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLS
GTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRYTGTTPSPPP
GSHYTSPSE

Ligand information

>7os4 Chain G (length=10) Species: 10090 (Mus musculus)

GKAPRKQLAT

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7os4 Structural Studies Provide New Insights into the Role of Lysine Acetylation on Substrate Recognition by CARM1 and Inform the Design of Potent Peptidomimetic Inhibitors.
• Resolution: 2.54 Å
• Binding residue (original residue number in PDB): F153 Y154 Q159 N162 M163 D166 E258 Y262 E267 H415 Y417 K471 F475
• Binding residue (residue number reindexed from 1): F17 Y18 Q23 N26 M27 D30 E122 Y126 E131 H279 Y281 K335 F339

Enzymatic activity

• Enzyme Commision number: 2.1.1.319: type I protein arginine methyltransferase.

Gene Ontology

Molecular Function

• GO:0016274 protein-arginine N-methyltransferase activity

Biological Process

• GO:0018216 peptidyl-arginine methylation

External links

• PDB: RCSB:7os4, PDBe:7os4, PDBj:7os4
• PDBsum: 7os4
• PubMed: 34569136
• UniProt: Q9WVG6|CARM1_MOUSE Histone-arginine methyltransferase CARM1 (Gene Name=Carm1)