Structure of PDB 7opl Chain C Binding Site BS01

Receptor Information
>7opl Chain C (length=389) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
METFDPTELPELLKLYYRRLFPYSQYYRWLNYGGVIKNYFQHREFSFTLK
DDIYIRYQSFNNQSDLEKEMQKMNPYKIDIGAVYSHRPNQHNTVKLGAFQ
AQEKELVFDIDMTDYDDVRRCCSSADICPKCWTLMTMAIRIIDRALKEDF
GFKHRLWVYSGRRGVHCWVCDESVRKLSSAVRSGIVEYLSLVKGGQDVKK
KVHLSEKIHPFIRKSINIIKKYFEEYALVNQDILENKESWDKILALVPET
IHDELQQSFQKSHNSLQRWEHLKKVASRYQNNIGPWLEWEIMLQYCFPRL
DINVSKGINHLLKSPFSVHPKTGRISVPIDLQKVDQFDPFTVPTISFICR
ELDAIRTRDYKKTSLAPYVKVFEHFLENLDKSRKGELLK
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7opl Chain C Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7opl Structural basis for the interaction of SARS-CoV-2 virulence factor nsp1 with DNA polymerase alpha-primase.
Resolution4.12 Å
Binding residue
(original residue number in PDB)		C121 C122 C128 C131
Binding residue
(residue number reindexed from 1)		C121 C122 C128 C131
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.102: DNA primase AEP.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003896 DNA primase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0032553 ribonucleotide binding
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0006269 DNA replication, synthesis of primer
GO:0006270 DNA replication initiation
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005654 nucleoplasm
GO:0005658 alpha DNA polymerase:primase complex
GO:0016020 membrane
GO:1990077 primosome complex

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7opl, PDBe:7opl, PDBj:7opl
PDBsum7opl
PubMed34719824
UniProtP49642|PRI1_HUMAN DNA primase small subunit (Gene Name=PRIM1)

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