Structure of PDB 7of2 Chain C Binding Site BS01

Receptor Information
>7of2 Chain C (length=401) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GTQRVCLVHPDVWQVAEATALVHTLDGWSVVQTMVVSTKTPDRKLIFGKG
NFEHLTEKIRGSPDITCVFLNVERMAAPTKKELEAAWGVEVFDRFTVVLH
IFRCNARTKEARLQVALAEMPLHRSNLKRDVAHLYRGVGSRYIMGSGESF
MQLQQRLLREKEAKIRKALDRLRKKRHLLRRQRTRREFPVISVVGYTNCG
KTTLIKALTGDAAIQPRDQLFATLDVTAHAGTLPSRMTVLYVDTIGFLSQ
LPHGLIESFSATLEDVAHSDLILHVRDVSHPEAELQKCSVLSTLRGLQLP
APLLDSMVEVHNKVDLVNVVPVSALRGHGLQELKAELDAAVLKATGRQIL
TLRVRLAGAQLSWLYKEATVQEVDVIPEDGAADVRVIISNSAYGKFRKLF
P
Ligand information
>7of2 Chain A (length=1410) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcuaaaccuagccccaaaccccaccuuacuaccagacaaccuuagccaaa
ccauuuacauaaaguauaggcgauagaaauugauggcgcaauagauauag
uaccgcaagggaaagaugaaaaaccaagcauaauauagcaaggacuaacc
ccuauaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagag
ccaaagcuaagacccccgaaaccagacgagcuaccuaagaacagcuaaaa
gagcacacccgucuauguagcaaaauagugggaagauuuauagguagagg
cgacaaaccuaccgagccuggugauagcugguuguccaagauagaaucuu
aguucaacuuuaaauuugcccacagaacccucuaaauccccuuguaaauu
uaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaaccu
uguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagcca
ccaauuaagaaagcguucaagcucaacacaaaaaucccaaacauauaacu
gaacuccucacacccaauuggaccaaucuaucacccuauagaagaacuaa
uguuaguauaaguaacaugaaaacauucuccuccgcauaagccugcguca
gauacugacaauuaacagcccaauaucuacaaucaaccaacaagucauua
uuacccucacugucaacccaacacaggcaugcucauaaggaaagguuaaa
aaaaguaaaaggaacucggcaaaucuuaccccgccuguuuaccaaaaaca
ucaccucuagcaucaccaguauuagaggcaccgccucacuuguuccuuaa
auagggaccuguauggcuccacgaggguucagcugucucuuacuuuuaac
cagugaaauugaccugcccgugaagaggcgggcauaacacagcaagacga
gaagacccuauggagcuuuaauuuauuaaugcaaacaccugcauuaaaaa
uuucgguuggggcgaccucggagcagaacccaaccuccgagcaguacaug
cuaagacuucaccagucaaagcgaaccucaauugauccaauaacuugacc
aacggaacaaguuacccuagggauaacagcgcaauccuauucuagagucc
auaucaacaauaggguuuacgaccucgauguuggaucaggacaucccgau
ggugcagccgcuauuaaagguucguuuguucaacgauuaaaguccuacgu
gaucugaguucagaccggaguaauccaggucgguuucuaucuacuuuaau
uccucccuguacgaaaggacaagagaaauaaggccuacuucacaaagcgc
cuucccccguaaaugauaucaucucaacuuaguauuauacccacacccaa
gaacaggguu
<<<.......<<<<.................................<..
....>...........<<.....>>.........>>.>>...........
..<<....>>................>>>...........<<<.......
>>>...<.<........>.>.<<<<<<.........<<<.<<..<<....
>>...>>.>>>...<<.<...<<<<.<.....<<<<<.<<<..<<<....
.>>>...<<<<.<<<<........>>>>>>>>....>>>.>>>>>...<<
.......>>......>.>>>>......>.>>..<<<<<<....<<<<...
.>>>><<<.<<<<<<<<<<.....<<..........>>.....>>>>>>>
>>>..>>>.<<<<<<<<<<......>>>>>>>>>>.<.<<<......>>>
.>..<<<.<<<...<..............<....<<<.........>>>.
...>.......<<<......>>>..........................>
...>>>>>>........>>>>>>...<<<<<......>>>>>........
.>>>>>><......<<..<<<....>>><<<<..<<<<........<<<<
<...>>>>>......<<<...<<<<.......................>>
>>.......>>>.....<<......>>.>>>>.....>>>>..<<<<...
<<<<<<<<.<<................<<<<<<..<<<.........>>>
...<<<<<<.............>>>>>>....<<<..<<..<<<<<<...
..>>>>>>..>>..>>>....>>.>>>>........>>.>>>>>>>>>>>
>.>>.....>.....<<<<<........>>>>>.......<<..<<<.<<
......<<<<.<<<<<<..<<<<<.<<<<<<<<......>>>>>>>>>>>
>>..<<<<.....>>>><<<<<<...........>>>>>>..<<.....<
<<..<<<<.....>>>>..>>>....>>.........<<<....>>>...
.........>>>>..>>>>>>.......<<<....<<<<<<...<<....
...>>...>>>>>>.....>>.>.......<<<<<..<<<<<..<<.<<<
<<<......>>>>>>...>>.<<<<<.....>>>>>.....>>>>>....
..>>>>.>....<<<<<<<....>>>.>>>>....>>..>>>.>>...<<
<.<<<.................>>>.>>><<<<<...<<<....>>>.>>
>>>......<<<................>>>.............<<<<..
.....>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7of2 Structural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		D148 R149 K150 R213 K215 R218 Y241 R242 G243 S246 R247 Y248 I249 M250 G251 G253 M257 L263 L285 R287 Q288 R289 R291 R292 F294 A334 L346 S505 G508 K509 K512
Binding residue
(residue number reindexed from 1)		D42 R43 K44 R107 K109 R112 Y135 R136 G137 S140 R141 Y142 I143 M144 G145 G147 M151 L157 L179 R181 Q182 R183 R185 R186 F188 A228 L240 S391 G394 K395 K398
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005525 GTP binding
GO:0043022 ribosome binding
GO:0046872 metal ion binding
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:7of2, PDBe:7of2, PDBj:7of2
PDBsum7of2
PubMed34135319
UniProtO43824|GTPB6_HUMAN Putative GTP-binding protein 6 (Gene Name=GTPBP6)

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