Structure of PDB 7n9h Chain C Binding Site BS01
Receptor Information
>7n9h Chain C (length=422) Species:
9606
(Homo sapiens) [
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NWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLIPKF
VSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASP
HAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLSTLACG
YLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADSCWA
ISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIVTGT
DEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVV
NHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGIIEP
LMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIE
ALQRHENESVYKASLNLIEKYF
Ligand information
>7n9h Chain A (length=23) Species:
9606
(Homo sapiens) [
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DNKRKMDETDASSAVKVKRAVQK
Receptor-Ligand Complex Structure
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PDB
7n9h
Determinants for TDP-43 Nuclear Localization Signal recognition and regulation by the importin alpha/beta heterodimer
Resolution
2.2 Å
Binding residue
(original residue number in PDB)
W142 N146 S149 G150 T151 T155 W184 N188 D192 W231 R238 K240 D270 W273 G281 N283 V321 T322 G323 W357 N361 A364 K392 E396 W399 N403
Binding residue
(residue number reindexed from 1)
W68 N72 S75 G76 T77 T81 W110 N114 D118 W157 R164 K166 D196 W199 G207 N209 V247 T248 G249 W283 N287 A290 K318 E322 W325 N329
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:7n9h
,
PDBe:7n9h
,
PDBj:7n9h
PDBsum
7n9h
PubMed
35767952
UniProt
P52292
|IMA1_HUMAN Importin subunit alpha-1 (Gene Name=KPNA2)
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