Structure of PDB 7n3y Chain C Binding Site BS01

Receptor Information

>7n3y Chain C (length=374) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GKSENTIRFLTFNVNGIRTFFHYQPFSQMNQSLRSVFDFFRADIITFQQL
KTEKLSISKWGRVDGFYSFISIPQTRKGYSGVGCWIRIPEKNHPLYHALQ
VVKAEEGITGYLTIKHSAISYRNDVNQGIGGYDSLDPDLDEKSALELDSE
GRCVMVELACGIVIISVYCPANSNSSEEGEMFRLRFLKVLLRRVRNLDKI
GKKIVLMGNVNVCRDLIDSADTLEQFSIPITDPMGGTKLEAQYRDKAIQF
IINPDTPHRRIFNQILADSLLPDASKRGILIDTTRLIQTRNRLKMYTVWN
MLKNLRPSNYGSRIDFILVSLKLERCIKAADILPDILGSDHCPVYSDLDI
LVPIPKFEARYKYNLRNHNVLEMF

Ligand information

>7n3y Chain E (length=13) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

tccgaaatuucgg

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	7n3y Molecular basis for processing of topoisomerase 1-triggered DNA damage by Apn2/APE2.
Resolution	2.73 Å
Binding residue (original residue number in PDB)	L284 D286
Binding residue (residue number reindexed from 1)	L271 D273

Enzymatic activity

Enzyme Commision number

3.1.11.2: exodeoxyribonuclease III.

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003824	catalytic activity
GO:0004518	nuclease activity
GO:0004519	endonuclease activity

	Biological Process
GO:0006281	DNA repair

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:7n3y, PDBe:7n3y, PDBj:7n3y
PDBsum	7n3y
PubMed	36198268
UniProt	P38207\|APN2_YEAST DNA-(apurinic or apyrimidinic site) endonuclease 2 (Gene Name=APN2)

[Back to BioLiP]