Structure of PDB 7n33 Chain C Binding Site BS01
Receptor Information
>7n33 Chain C (length=346) Species:
2697049
(Severe acute respiratory syndrome coronavirus 2) [
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EMSLENVAFNVVNKGHFDGQQGEVPVSIINNTVYTKVDGVDVELFENKTT
LPVNVAFELWAKRNIKPVPEVKILNNLGVDIAANTVIWDYKRDAPAHIST
IGVCSMTDIAKKPTETICAPLTVFFDGRVDGQVDLFRNARNGVLITEGSV
KGLQPSVGPKQASLNGVTLIGEAVKTQFNYYKKVDGVVQQLPETYFTQSR
NLQEFKPRSQMEIDFLELAMDEFIERYKLEGYAFEHIVYGDFSHSQLGGL
HLLIGLAKRFKESPFELEDFIPMDSTVKNYFITDAQTGSSKCVCSVIDLL
LDDFVEIIKSQDLSVVSKVVKVTIDYTEISFMLWCKDGHVETFYPK
Ligand information
>7n33 Chain I (length=2) [
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..
Receptor-Ligand Complex Structure
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PDB
7n33
Characterization of SARS2 Nsp15 nuclease activity reveals it's mad about U.
Resolution
2.5 Å
Binding residue
(original residue number in PDB)
G248 H250 K290 V292 C293 S294 Y343
Binding residue
(residue number reindexed from 1)
G249 H251 K291 V293 C294 S295 Y344
Enzymatic activity
Enzyme Commision number
2.1.1.56
: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57
: methyltransferase cap1.
2.7.7.48
: RNA-directed RNA polymerase.
2.7.7.50
: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12
: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69
: SARS coronavirus main proteinase.
3.6.4.12
: DNA helicase.
3.6.4.13
: RNA helicase.
4.6.1.-
External links
PDB
RCSB:7n33
,
PDBe:7n33
,
PDBj:7n33
PDBsum
7n33
PubMed
34403466
UniProt
P0DTD1
|R1AB_SARS2 Replicase polyprotein 1ab (Gene Name=rep)
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