Structure of PDB 7mj5 Chain C Binding Site BS01

Receptor Information
>7mj5 Chain C (length=257) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTA
NVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDA
CEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWI
QKVIDQF
Ligand information
>7mj5 Chain P (length=29) Species: 163159 (Xenopsylla cheopis) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
EVAQPKLYQRGEGGNGMEPIPEDVLNEAL
Receptor-Ligand Complex Structure
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PDB7mj5 Identification of a substrate-like cleavage-resistant thrombin inhibitor from the saliva of the flea Xenopsylla cheopis.
Resolution2.15 Å
Binding residue
(original residue number in PDB)		E146 A149A R187 R222 D223
Binding residue
(residue number reindexed from 1)		E146 A150 R197 R233 D234
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:7mj5, PDBe:7mj5, PDBj:7mj5
PDBsum7mj5
PubMed34688666
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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