Structure of PDB 7mj1 Chain C Binding Site BS01

Receptor Information

>7mj1 Chain C (length=200) Species: 220668 (Lactiplantibacillus plantarum WCFS1)

NGFPEVIYGAGKTATQIVGIVQALSQQTLPILTTRLSAEKFAALQPALPT
AVYHATAQCMTVGEPAPKTPGYIAVVTAGTSDQPVAEEAAVTAETFGNRV
ERVYDVGVAGIHRLFAKLDVIRGARVVIVIAGMEGALASVVGGLVDKPVI
AVPTSVGYGTSFQGMTALLTMLNSCASGITVVNIDNGFGAAYSASMVNQM

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 7mj1 Chain C Residue 301

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7mj1 The LarB carboxylase/hydrolase forms a transient cysteinyl-pyridine intermediate during nickel-pincer nucleotide cofactor biosynthesis.
• Resolution: 3.402 Å
• Binding residue (original residue number in PDB): V191 S223
• Binding residue (residue number reindexed from 1): V145 S177
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.5.1.143: pyridinium-3,5-biscarboxylic acid mononucleotide synthase.

Gene Ontology

Molecular Function

• GO:0016740 transferase activity
• GO:0016787 hydrolase activity

Biological Process

• GO:0006189 'de novo' IMP biosynthetic process

Cellular Component

• GO:0005886 plasma membrane

External links

• PDB: RCSB:7mj1, PDBe:7mj1, PDBj:7mj1
• PDBsum: 7mj1
• PubMed: 34548397
• UniProt: F9UST0|LARB_LACPL Pyridinium-3,5-biscarboxylic acid mononucleotide synthase (Gene Name=larB)