Structure of PDB 7lt5 Chain C Binding Site BS01

Receptor Information
>7lt5 Chain C (length=560) Species: 272563 (Clostridioides difficile 630) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DNFLLSKEYENSLDVDTKKASGIYYTPKIIVDYIVKKTLKNHDIIKNPYP
RILDISCGCGNFLLEVYDILYDLFEENIYELKKKYDENYWTVDNIHRHIL
NYCIYGADIDEKAISILKDSLTNIKINLFCCDSLKKKWRYKFDYIVGNPP
YIGHKKLEKKYKKFLLEKYSEVYKDKADLYFCFYKKIIDILKQGGIGSVI
TPRYFLESLSGKDLREYIKSNVNVQEIVDFLGANIFKNIGVSSCILTFDK
KKTKETYIDVFKIKNEDICINKFETLEELLKSSKFEHFNINQRLLSDEWI
LVNKDDETFYNKIQEKCKYSLEDIAISFQGIITGCDKAFILSKDDVKLNL
VDDKFLKCWIKSKNINKYIVDKSEYRLIYSNDIDNENTNKRILDEIIGLY
KTKLENRRECKSGIRKWYELQWGREKLFFERKKIMYPYKSNENRFAIDYD
NNFSSADVYSFFIKEEYLDKFSYEYLVGILNSSVYDKYFKITAKKMSKNI
YDYYPNKVMKIRIFRDNNYEEIENLSKQIISILLNKSIDKGKVEKLQIKM
DNLIMDSLGI
Ligand information
Receptor-Ligand Complex Structure
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PDB7lt5 Clostridioides difficile specific DNA adenine methyltransferase CamA squeezes and flips adenine out of DNA helix.
Resolution2.54 Å
Binding residue
(original residue number in PDB)		K25 Y30 N165 Y168 K193 Y221 S227 F253 I256 G257 Q346 I431 R432 W439 R441 K456 Y476 K511 M513 S514 Y521 P522 N523
Binding residue
(residue number reindexed from 1)		K19 Y24 N148 Y151 K176 Y204 S210 F236 I239 G240 Q329 I414 R415 W422 R424 K439 Y459 K494 M496 S497 Y504 P505 N506
Enzymatic activity
Enzyme Commision number 2.1.1.72: site-specific DNA-methyltransferase (adenine-specific).
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008168 methyltransferase activity
GO:0009007 site-specific DNA-methyltransferase (adenine-specific) activity
Biological Process
GO:0006304 DNA modification
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7lt5, PDBe:7lt5, PDBj:7lt5
PDBsum7lt5
PubMed34103525
UniProtQ183J3

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