Structure of PDB 7lri Chain C Binding Site BS01

Receptor Information

>7lri Chain C (length=554) Species: 11676 (Human immunodeficiency virus 1)

PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKI
GPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGL
KKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLP
QGWKGSPAIFQSSMTKILEPFKKQNPDIVIYQYMDDLYVGSDLEIGQHRT
KIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKD
SWTVNDIQKLVGKLNWASQIYPGIKVRQLSKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLK
TGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWET
WWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVDGAANRET
KLGKAGYVTNKGRQKVVPLTNTTNQKTELQAIYLALQDSGLEVNIVTNSQ
YALGIIQAQPDKSESELVNQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDK
LVSA

Ligand information

>7lri Chain F (length=35)

tacccccccttcggtgctttgcaccgaaggggggg

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7lri Structural basis of HIV inhibition by L-nucleosides: Opportunities for drug development and repurposing.
• Resolution: 3.05 Å
• Binding residue (original residue number in PDB): W24 L74 D76 R78 E89 I94 G152 W153 K154 P157 Y183 D185 M230 G231 Q258 G262 K263 W266 S280 R284 G285 L289 K353 R358 G359 H361 R448 T473 Q475 K476 Y501
• Binding residue (residue number reindexed from 1): W24 L74 D76 R78 E89 I94 G152 W153 K154 P157 Y183 D185 M230 G231 Q258 G262 K263 W266 S280 R284 G285 L289 K353 R358 G359 H361 R448 T473 Q475 K476 Y501

Enzymatic activity

• Enzyme Commision number: 2.7.7.-
  2.7.7.49: RNA-directed DNA polymerase.
  2.7.7.7: DNA-directed DNA polymerase.
  3.1.-.-
  3.1.13.2: exoribonuclease H.
  3.1.26.13: retroviral ribonuclease H.
  3.4.23.16: HIV-1 retropepsin.

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003964 RNA-directed DNA polymerase activity
• GO:0004523 RNA-DNA hybrid ribonuclease activity

Biological Process

• GO:0006278 RNA-templated DNA biosynthetic process

External links

• PDB: RCSB:7lri, PDBe:7lri, PDBj:7lri
• PDBsum: 7lri
• PubMed: 35218925
• UniProt: P03366|POL_HV1B1 Gag-Pol polyprotein (Gene Name=gag-pol)