Structure of PDB 7lrc Chain C Binding Site BS01

Receptor Information
>7lrc Chain C (length=371) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KPILAPEPLVMDNLDSIMEQLNTWNFPIFDLVENIGRKCGRILSQVSYRL
FEDMGLFEAFKIPIREFMNYFHALEIGYRDIPYHNRIHATDVLHAVWYLT
TQPIPGLSTVGYVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYD
HPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYNFLINL
DHVEFKHFRFLVIEAILATDLKKHFDFVAKFNGKVNDDVGIDWTNENDRL
LVCQMCIKLADINGPAKCKELHLQWTDGIVNEFYEQGDEEASLGLPISPF
MDRSAPQLANLQESFISHIVGPLCNSYDSAGLMPGKWVERKIYCQITQHL
LQNHKMWKKVIEEEQRLAGIE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7lrc Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase.
Resolution2.97 Å
Binding residue
(original residue number in PDB)		L910 K911 F914 P988 F989 S1003 H1007
Binding residue
(residue number reindexed from 1)		L221 K222 F225 P299 F300 S314 H318
Enzymatic activity
Enzyme Commision number 3.1.4.17: 3',5'-cyclic-nucleotide phosphodiesterase.
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:7lrc, PDBe:7lrc, PDBj:7lrc
PDBsum7lrc
PubMed34272366
UniProtQ14432|PDE3A_HUMAN cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (Gene Name=PDE3A)

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