Structure of PDB 7lqz Chain C Binding Site BS01

Receptor Information
>7lqz Chain C (length=651) Species: 43179 (Ictidomys tridecemlineatus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LKLYDRRSIFDAVAQNNCQELESLLPFLQKSRKRLTDSEFKDPETGKTCL
LKAMLNLHNGQNDTISLLLDIARQTDSLKEFVNASYTDSYYKGQTALHIA
IERRNMALVTLLVENGADVQAAANGDFFKKTKGRPGFYFGELPLSLAACT
NQLAIVKFLLQNSWQPADISARDSVGNTVLHALVEVADNTADNTKFVTSM
YNEILILGAKLHPTLKLEELINKKGLTPLALAASSGKIGVLAYILQREIQ
EPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPN
RHDMLLVEPLNRLLQDKWDRFVKRIFYFNFFVYCLYMIVFTTAAYYRPVD
GLPPYKLKNTVGDYFRVTGEILSVSGGVYFFLRGIQYFLQRRPSMKTLFV
DSYSEMLFFVQSLFMLGSVVLYFSHRKEYVASMVFSLAMGWTNMLYYTRG
FQQMGIYAVMIEKMILRDLCRFMFVYLVFLFGFSTAVVTLIEDGKNPPDS
YNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLN
MLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKAFRSGKLL
QVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNCEGVKRTLSFS
L
Ligand information
Ligand ID6EU
InChIInChI=1S/C37H40O9/c1-21(2)35-17-23(4)37-27(33(35)44-36(45-35,46-37)19-24-9-7-6-8-10-24)14-26(18-34(41)30(37)13-22(3)32(34)40)20-43-31(39)16-25-11-12-28(38)29(15-25)42-5/h6-15,23,27,30,33,38,41H,1,16-20H2,2-5H3/t23-,27+,30-,33-,34-,35-,36-,37-/m1/s1
InChIKeyDSDNAKHZNJAGHN-MXTYGGKSSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.4CC1CC2(C3C4C1(C5C=C(C(=O)C5(CC(=C4)COC(=O)Cc6ccc(c(c6)OC)O)O)C)OC(O3)(O2)Cc7ccccc7)C(=C)C
CACTVS 3.385COc1cc(CC(=O)OCC2=C[CH]3[CH]4O[C]5(Cc6ccccc6)O[C]4(C[CH](C)[C]3(O5)[CH]7C=C(C)C(=O)[C]7(O)C2)C(C)=C)ccc1O
CACTVS 3.385COc1cc(CC(=O)OCC2=C[C@H]3[C@H]4O[C@]5(Cc6ccccc6)O[C@]4(C[C@@H](C)[C@]3(O5)[C@@H]7C=C(C)C(=O)[C@@]7(O)C2)C(C)=C)ccc1O
ACDLabs 12.01COc1cc(ccc1O)CC(=O)OCC=3CC2(C(C=C(C2=O)C)C54C(C=3)C6C(CC4C)(OC(O5)(O6)Cc7ccccc7)\C(=C)C)O
OpenEye OEToolkits 2.0.4C[C@@H]1C[C@]2([C@H]3[C@H]4[C@]1([C@@H]5C=C(C(=O)[C@]5(CC(=C4)COC(=O)Cc6ccc(c(c6)OC)O)O)C)O[C@](O3)(O2)Cc7ccccc7)C(=C)C
FormulaC37 H40 O9
Nameresiniferatoxin;
RTX
ChEMBLCHEMBL17976
DrugBankDB06515
ZINCZINC000004262463
PDB chain7lqz Chain B Residue 903 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7lqz Extracellular cap domain is an essential component of the TRPV1 gating mechanism.
Resolution3.41 Å
Binding residue
(original residue number in PDB)		F593 L671
Binding residue
(residue number reindexed from 1)		F483 L543
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005230 extracellular ligand-gated monoatomic ion channel activity
GO:0005261 monoatomic cation channel activity
GO:0005262 calcium channel activity
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0051219 phosphoprotein binding
GO:0097603 temperature-gated ion channel activity
Biological Process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001659 temperature homeostasis
GO:0001660 fever generation
GO:0002024 diet induced thermogenesis
GO:0002790 peptide secretion
GO:0006629 lipid metabolic process
GO:0006811 monoatomic ion transport
GO:0006816 calcium ion transport
GO:0009268 response to pH
GO:0009408 response to heat
GO:0014832 urinary bladder smooth muscle contraction
GO:0019233 sensory perception of pain
GO:0034220 monoatomic ion transmembrane transport
GO:0034605 cellular response to heat
GO:0048265 response to pain
GO:0048266 behavioral response to pain
GO:0050909 sensory perception of taste
GO:0050954 sensory perception of mechanical stimulus
GO:0050955 thermoception
GO:0050960 detection of temperature stimulus involved in thermoception
GO:0050965 detection of temperature stimulus involved in sensory perception of pain
GO:0050968 detection of chemical stimulus involved in sensory perception of pain
GO:0055085 transmembrane transport
GO:0060083 smooth muscle contraction involved in micturition
GO:0070588 calcium ion transmembrane transport
GO:0071468 cellular response to acidic pH
GO:0098703 calcium ion import across plasma membrane
GO:1901594 response to capsazepine
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0032591 dendritic spine membrane
GO:0043005 neuron projection
GO:0045211 postsynaptic membrane
GO:0098982 GABA-ergic synapse

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7lqz, PDBe:7lqz, PDBj:7lqz
PDBsum7lqz
PubMed33846324
UniProtI3LZN5

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