Structure of PDB 7lhz Chain C Binding Site BS01

Receptor Information

>7lhz Chain C (length=714) Species: 507522 (Klebsiella pneumoniae 342)

GKLADCTAQDLNRTELFLVEGDSAGGSAKQARDREYQAIMPLKGKILNTW
EVSSDEVLASQEVHDISVAIGIDPDSDDLSQLRYGKICILADADSDGLHI
ATLLCALFVRHFRTLVKEGHVYVALPPLYRIDLGKEVYYALTEEEKTGVL
EQLKRKKGKPNVQRFKGLGEMNPMQLRETTLDPNTRRLVQLVISDEDEQQ
TTAIMDMLLAKKRSEDRRNWLQEKGDMADLMSDMAERLALHEFTENAYLN
YSMYVIMDRALPFIGDGLKPVQRRIVYAMSELGLNASAKFKKSARTVGDV
LGKYHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRY
TESRLSKYAELLLSELGQGTVDWVPNFDGTLQEPKMLPARLPNILLNGTT
GIAVGMATDIPPHNLREVAKAAITLIEQPKTTLDELLDIVQGPDFPTEAE
IITSRAEIRKIYQNGRGSVRMRAVWSKEDGAVVITALPHQVSGAKVLEQI
AAQMRNKKLPMVDDLRDESDHENPTRLVIVPRSNRVDMEQVMNHLFATTD
LEKSYRINLNMIGLDGRPAVKNLLEILSEWLVFRRDTVRRRLNHRLEKVL
KRLHILEGLLVAFLNIDEVIEIIRTEDEPKPALMSRFGISETQAEAILEL
KLRHLAKLEEMKIRGEQSELEKERDQLQAILASERKMNNLLKKELQADAD
AFGDDRRSPLHERE

Ligand information

>7lhz Chain P (length=10)

tacgttgtat

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7lhz Discovery and Optimization of DNA Gyrase and Topoisomerase IV Inhibitors with Potent Activity against Fluoroquinolone-Resistant Gram-Positive Bacteria.
• Resolution: 3.3 Å
• Binding residue (original residue number in PDB): E419 K444 D495 R1029 K1039 V1041 H1075 H1077 G1078 L1088 T1170 I1172
• Binding residue (residue number reindexed from 1): E20 K45 D96 R259 K269 V271 H305 H307 G308 L318 T400 I402

Enzymatic activity

• Enzyme Commision number: 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
• GO:0005524 ATP binding

Biological Process

• GO:0006259 DNA metabolic process
• GO:0006265 DNA topological change

Cellular Component

• GO:0005694 chromosome

External links

• PDB: RCSB:7lhz, PDBe:7lhz, PDBj:7lhz
• PDBsum: 7lhz
• PubMed: 33929852
• UniProt: B5XU53;
  B5XU60