Structure of PDB 7jtn Chain C Binding Site BS01

Receptor Information
>7jtn Chain C (length=702) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QGSCSLEGVEIKGGSFRLLQEGQALEYVCPSGFYPYPVQTRTCRSTGSWS
TLKTKTVRKAECRAIHCPRPHDFENGEYWPRSPYYNVSDEISFHCYDGYT
LRGSANRTCQVNGRWSGQTAICDNGAGYCSNPGIPIGTRKVGSQYRLEDS
VTYHCSRGLTLRGSQRRTCQEGGSWSGTEPSCQDSFMYDTPQEVAEAFLS
SLTETIKRKIVLDPSGSMNIYLVLDGSDSIGASNFTGAKKCLVNLIEKVA
SYGVKPRYGLVTYATYPKIWVKVSEADSSNADWVTKQLNEINYEGTNTKK
ALQAVYSMMSWPDDVPPEGWNRTRHVIILMTDGLHNMGGDPITVIDEIRD
LLYIGKDRKNPREDYLDVYVFGVGPLVNQVNINALASKKDNEQHVFKVKD
MENLEDVFYQMIDESQSLSLCGMVWEHRKGTDYHKQPWQAKISVIRPSKG
HESCMGAVVSEYFVLTAAHCFTVDDKEHSIKVSVGGEKRDLEIEVVLFHP
NYNINGKKEAGIPEFYDYDVALIKLKNKLKYGQTIRPICLPCTEGTTRAL
RLPPTTTCQQQKEELLPAQDIKALFVSEEEKKLTRKEVYIKNGDKKGSCE
RDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHK
RSRFIQVGVISWGVVDVCKNQVPAHARDFHINLFQVLPWLKEKLQDEDLG
FL
Ligand information
>7jtn Chain B (length=30) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcugagaauagaaguaggaguaugcuugcu
<<..<<..................>>.>>.
Receptor-Ligand Complex Structure
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PDB7jtn Inhibition of the Complement Alternative Pathway by Chemically Modified DNA Aptamers That Bind with Picomolar Affinity to Factor B.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		E519 R521 K562
Binding residue
(residue number reindexed from 1)		E487 R489 K530
Enzymatic activity
Enzyme Commision number 3.4.21.47: alternative-complement-pathway C3/C5 convertase.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0006956 complement activation
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7jtn, PDBe:7jtn, PDBj:7jtn
PDBsum7jtn
PubMed33419768
UniProtP00751|CFAB_HUMAN Complement factor B (Gene Name=CFB)

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