Structure of PDB 7js3 Chain C Binding Site BS01

Receptor Information

>7js3 Chain C (length=325) Species: 263 (Francisella tularensis)

KVALEAVRVTELAALASWSQMGRGDKIAADQAAVDAMRKALNEVDIDGTV
VIGEGELDEAPMLYIGEKVGAGGCEVDIALDPLEGTTITSKGGANALTVL
AMADKGGFLNAPDVYMQKIAVGGINAPKGIVDLDDSVTNNLKRIAEFKGV
HMSALVVCTMDRPRHEHIIKEARECGARVILINDGDVSGVIATATENSGI
DVYIGTGGAPEGVLAAAALKCLGGQMQARLIFNDEEEIKRAHRLGITDLN
KKYDIDDLASGDIVFAATGVTDGNMLQGVKRVNSTRRGSYAVTHSVVMRS
TTKTVRHITAEHSFDFKEGIEKFMS

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 7js3 Chain C Residue 401

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7js3 Structural and biochemical characterization of the class II fructose-1,6-bisphosphatase from Francisella tularensis.
• Resolution: 2.4 Å
• Binding residue (original residue number in PDB): D84 L86 E87
• Binding residue (residue number reindexed from 1): D81 L83 E84
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.1.3.11: fructose-bisphosphatase.

Gene Ontology

Molecular Function

• GO:0016787 hydrolase activity
• GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006071 glycerol metabolic process
• GO:0006094 gluconeogenesis
• GO:0030388 fructose 1,6-bisphosphate metabolic process

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:7js3, PDBe:7js3, PDBj:7js3
• PDBsum: 7js3
• PubMed: 33135671
• UniProt: Q5NEJ8