Structure of PDB 7f75 Chain C Binding Site BS01

Receptor Information
>7f75 Chain C (length=1133) Species: 1423 (Bacillus subtilis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VQYGRHRQRRSYARISEVLELPNLIEIQTSSYQWFLDEGLREMFQDISPI
EDFTGNLSLEFIDYSLGEPKYPVEESKERDVTYSAPLRVKVRLINKETGE
VKDQDVFMGDFPIMTDTGTFIINGAERVIVSQLVRSPSVYFSGKVDKNGK
KGFTATVIPNRGAWLEYETDAKDVVYVRIDRTRKLPVTVLLRALGFGSDQ
EILDLIGENEYLRNTLDKDNTENSDKALLEIYERLRPGEPPTVENAKSLL
DSRFFDPKRYDLANVGRYKINKKLHIKNRLFNQRLAETLVDRRTLDKVLP
YLENGIGFRKLYPNGGVVEDEVTLQSIKIFAPTDQEGEQVINVIGNAYIE
EEIKNITPADIISSISYFFNLLHGVGDTDDIDHLGNRRLRSVGELLQNQF
RIGLSRMERVVRERMSIQDTNTITPQQLINIRPVIASIKEFFGSSQLSQF
MDQTNPLAELTHKRRLSALGPGGLTRERAGMEVRDVHYSHYGRMCPIETP
EGPNIGLINSLSSYAKVNRFGFIETPYRRVDPETGKVTGRIDYLTADEED
NYVVAQANARLDDEGAFIDDSIVARFRGENTVVSRNRVDYMDVSPKQVVS
AATACIPFLENDDSNRALMGANMQRQAVPLMQPEAPFVGTGMEYVSGKDS
GAAVICKHGIVERVEAKNVWVRRYEEVDGQKVKGNLDKYSLLKFVRSNQG
TCYNQRPIVSVGDEVVKGEILADGPSMELGELALGRNVMVGFMTWDGYNY
EDAIIMSERLVKDDVYTSIHIEEYESEARDTKLGPEEITRDIPNVGEDAL
RNLDDRGIIRIGAEVKDGDLLVGKVTPKGVTELTAEERLLHAIFGEKARE
VRDTSLRVPHGGGGIIHDVKVFNREDGDELPPGVNQLVRVYIVQKRKISE
GDKMAGRHGNKGVISKILPEEDMPYLPDGTPIDIMLNPLGVPSRMNIGQV
LELHMGMAARYLGIHIASPVFDGAREEDVWETLEEAGMSRDAKTVLYDGR
TGEPFDNRVSVGIMYMIKLAHMVDDKLHARSTGPYSLVTQQPLGGKAQFG
GQRFGEMEVWALEAYGAAYTLQEILTVKSDDVVGRVKTYEAIVKGDNVPE
PGVPESFKVLIKELQSLGMDVKILSGDEEEIEM
Ligand information
>7f75 Chain J (length=59) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agcattaaaatagcgtgaacgaatgggagatgcttataatgggagctgtc
acggatgca
Receptor-Ligand Complex Structure
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PDB7f75 Structural basis of transcription activation by the global regulator Spx.
Resolution4.2 Å
Binding residue
(original residue number in PDB)		R186 R241 E244
Binding residue
(residue number reindexed from 1)		R181 R236 E239
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0046677 response to antibiotic
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7f75, PDBe:7f75, PDBj:7f75
PDBsum7f75
PubMed34530448
UniProtP37870|RPOB_BACSU DNA-directed RNA polymerase subunit beta (Gene Name=rpoB)

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