Structure of PDB 7dhy Chain C Binding Site BS01

Receptor Information
>7dhy Chain C (length=194) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQL
WVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLI
RVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGS
MNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENL
Ligand information
Ligand IDARS
InChIInChI=1S/AsH3/h1H3
InChIKeyRBFQJDQYXXHULB-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[As]
ACDLabs 10.04[AsH3]
FormulaAs
NameARSENIC
ChEMBLCHEMBL1231052
DrugBank
ZINC
PDB chain7dhy Chain C Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7dhy Arsenic Trioxide Rescues Structural p53 Mutations through a Cryptic Allosteric Site.
Resolution2.15 Å
Binding residue
(original residue number in PDB)		C124 M133 C135 C141
Binding residue
(residue number reindexed from 1)		C29 M38 C40 C46
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0006915 apoptotic process
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7dhy, PDBe:7dhy, PDBj:7dhy
PDBsum7dhy
PubMed33357454
UniProtP04637|P53_HUMAN Cellular tumor antigen p53 (Gene Name=TP53)

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