Structure of PDB 7dd9 Chain C Binding Site BS01

Receptor Information
>7dd9 Chain C (length=1129) Species: 83333,284812 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TLFPVLNNTPVGKQVDSIYESRLDQFLSEGQYRDFNLPSVYDHARIDNPS
GDVNNDLSKGFVDLKVYRVPDLSRPSFNEVVGHKKFDETASKGDTFGPSW
ATFWFEVHIRLPKSWAKYEQVIFQWNCDNEGLVYSQDGVPLQAFSGSERT
DFILPDSWKTTEDTFYIEMACNGMFGTGAGSQIAPPDPNRYFTLTKADLV
APNLPAMALAYDFLLMQQCVKQLPSNCWQKYKARQICNDIMNTFHPNDLS
TINECRNLAKAFLGNDIDSEAVFEKNNDKANVFAIGHCHIDTAWLWPFAE
TRRKIVRSWATQMNIMDRYPEYQFVCSQALQYLWLKEDHPDVFEKLKEYV
NQNKFIPIGGSWVEHDTNIPNGESLIRQFLLGQHFFEKEFGVRCRTFWLP
DTFGYSSQIPQICRLCGMDRFLTQKLSWNNINSFPTSTFNWVALDGSQVI
CHMPPANTYTADTNVNDVLHSIDQHKNLVNDQAGLLVFGIGDGGGGPTPE
MLEKLRRCKGIANTVGYLPNVKLGNTVDEFFDGILKRTNAGQTLPSWNGE
LYFEFHRGTYTTQAELKKLMRKVEIALHDAEYVSTLASIFSKDYSYPKES
LQDLWRDTLLCQFHDVLPGSCIEMVYKDAIPIMSKVLKNTEALLWQAIEQ
LGFKKASSSDNKEQLCLLNTLPWNVRGVITETEENKLVYFESCDGKGILT
AAHTSLKHPAAAYQKDDNFILVNDHLRVTIAPNGLILSLFDLHKEREILD
LKSGKNHAGANQYVLFEDTPLSWQAWDTEVFSLEKYEVLDKGKVSIKESG
PLRASVVVDIPISELSHMKATISLEGYNDCSEFTGVNFTCEVDWHESCKF
LKVEFPVDIHSEFASYETQFGITKRPTHYNTSWDVAKFEVCHQKFADYSD
FTYGVSVLNDCKYGFSTHGNLMRLSLLRSPKQPDAHADMGKHTIRYAVYP
HSKPLDSSTVRAAHKFNSNFRLLTRASDTANLDIFDAFQLVGEPNVILSH
IKMAEKGKSIILRVYESLGGKSRARLVIKSLTVASVTKCNGLEEDLEELC
TLKSNDYYEVPIELRAFEIATFKVNLGFKSVACNTCLKIIRNDSFHCTKC
FDFDVCRDCYAKQAFLHPCPKPHFVLVRS
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7dd9 Chain C Residue 1601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7dd9 Molecular and structural mechanisms of ZZ domain-mediated cargo selection by Nbr1.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		H290 D292 D402 H615
Binding residue
(residue number reindexed from 1)		H289 D291 D401 H614
Annotation score4
Enzymatic activity
Enzyme Commision number 3.2.1.24: alpha-mannosidase.
Gene Ontology
Molecular Function
GO:0004559 alpha-mannosidase activity
GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0046872 metal ion binding
GO:0052767 mannosyl-oligosaccharide 1,6-alpha-mannosidase activity
GO:0052768 mannosyl-oligosaccharide 1,3-alpha-mannosidase activity
GO:1901982 maltose binding
Biological Process
GO:0006013 mannose metabolic process
GO:0006974 DNA damage response
GO:0008643 carbohydrate transport
GO:0009313 oligosaccharide catabolic process
GO:0015768 maltose transport
GO:0034219 carbohydrate transmembrane transport
GO:0034289 detection of maltose stimulus
GO:0042956 maltodextrin transmembrane transport
GO:0055085 transmembrane transport
GO:0060326 cell chemotaxis
Cellular Component
GO:0000328 fungal-type vacuole lumen
GO:0000329 fungal-type vacuole membrane
GO:0005737 cytoplasm
GO:0005773 vacuole
GO:0005829 cytosol
GO:0016020 membrane
GO:0030288 outer membrane-bounded periplasmic space
GO:0042597 periplasmic space
GO:0043190 ATP-binding cassette (ABC) transporter complex
GO:0055052 ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
GO:1990060 maltose transport complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7dd9, PDBe:7dd9, PDBj:7dd9
PDBsum7dd9
PubMed34169534
UniProtP0AEX9|MALE_ECOLI Maltose/maltodextrin-binding periplasmic protein (Gene Name=malE);
Q9P792;
Q9UT61|MAN1_SCHPO Alpha-mannosidase (Gene Name=ams1)

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