Structure of PDB 7d1a Chain C Binding Site BS01

Receptor Information
>7d1a Chain C (length=447) Species: 1359 (Lactococcus cremoris) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TMAILERISKNSQENIDEVFTRLYRYLLRPDIYYVAYQNLYSNKGASTKG
ILDDTADGFSEEKIKKIIQSLKDGTYYPQPVRRMYIAKKNSKKMRPLGIP
TFTDKLIQEAVRIILESIYEPVFEDVSHGFRPQRSCHTALKTIKREFGGA
RWFVEGDIKGCFDNIDHVTLIGLINLKIKDMKMSQLIYKFLKAGYLENWQ
YHKTYSGTPQGGILSPLLANIYLHELDKFVLQLKMKFDRESPERITPEKY
VRYADDFIISVKGSKEDCQWIKEQLKLFIHNKLKMELSEEKTLITHSSQP
ARFLGYDIRVVKKRTLNGSVELLIPLQDKIRQFIFDKKIAIQKKDSSWFP
VHRKYLIRSTDLEIITIYNSELRGICNYYGLASNFNQLNYFAYLMEYSCL
KTIASKHKGTLSKTISMFKDGSGSWGISQAPVLYGYARNTLENRLKA
Ligand information
>7d1a Chain A (length=692) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gugcgcccagauaggguguuaagucaaguaguuuaagguacuacucugua
agauaacacagaaaacagccaaccuaaccgaaaagcgaaagcugauacgg
gaacagagcacgguuggaaagcgaugaguuaccuaaagacaaucggguac
gacugagucgcaauguuaaucagauauaagguauaaguuguguuuacuga
acgcaaguuucuaauuucgguuaugugucgauagaggaaagugucugaaa
ccucuaguacaaagaaagguaaguuaugguuguggacuuaucuguuauca
ccacauuuguacaaucuguaggagaaccuaugggaacgaaacgaaagcga
ugccgagaaucugaauuuaccaagacuuaacacuaacuggggauacccua
aacaagaaugccuaaaggaggaaaaaggcuauagcacuagagcuugaaaa
ucuugcaaggguacggaguacucguaguagucugagaaggguaacgcccu
uuacauggcaaagggguacaguuauuguguacuaaaauuaaaaauugauu
agggaggaaaaccucaaaccaacaauggcaauuuuagacaauaacagagc
cguauacuccgagagggguacguacgguucccgaagaggguggugcaaac
cagucacaguaaugugaacaaggcgguaccucccuacuucac
.....<<<<.....<<<<<<<<<<<..<<<<.........>>>><<<<..
....(((.>>>>.<<<<.<<<<<<...<....<.<<....>>>.....>.
...........>>>>>>...<<<<..<<..<.<...((.......>.>..
..>>...>>>>..>>>>...<<<<.....<<<<..<<<.......>>>..
..<<...<<<<.......<<.......>>...............))....
.......<<<<<<....<<<<<<<<.........>>>>>>>>.)))....
.....>>>>>>......<<<<......>>>>......>>>>.....>>..
>>>>.....>>>>..........>>>>>>>>>>>...>>>>..<<<<...
..<.......<<<..>>>........<<<<..<....>..>>>>......
....>...>>.>>....<<.<<<.............<<<<<.....>>>>
>...........>>>..>>.<<<<<<<.......................
.....<<.....>>........................>>>>>>>.<<<<
<<<<<<<<<<....>>>>>..>>>>>>>>>..<<<.<<<<.<..<<....
.......<....>............>>...>>>>>..>>>..
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7d1a Exon and protein positioning in a pre-catalytic group II intron RNP primed for splicing.
Resolution3.8 Å
Binding residue
(original residue number in PDB)
A6 R10 K13 N14 E17 N18 E21 Y29 R32 P33 Y36 Y37 L74 Y79 R154 K185 M186 S187 Q188 Y198 E200 W202 Q203 Y204 R247 I248 T249 P250 E251 H349 V375 R378 Q406 K407 D409 F413 N450 Y454 W489
Binding residue
(residue number reindexed from 1)
A3 R7 K10 N11 E14 N15 E18 Y26 R29 P30 Y33 Y34 L71 Y76 R151 K182 M183 S184 Q185 Y195 E197 W199 Q200 Y201 R244 I245 T246 P247 E248 H296 V311 R314 Q342 K343 D345 F349 N386 Y390 W425
Enzymatic activity
Enzyme Commision number 2.7.7.49: RNA-directed DNA polymerase.
3.1.-.-
Gene Ontology
Molecular Function
GO:0003964 RNA-directed DNA polymerase activity
GO:0004519 endonuclease activity
Biological Process
GO:0006278 RNA-templated DNA biosynthetic process
GO:0006314 intron homing
GO:0006397 mRNA processing
GO:0006974 DNA damage response

View graph for
Molecular Function

View graph for
Biological Process
External links
PDB RCSB:7d1a, PDBe:7d1a, PDBj:7d1a
PDBsum7d1a
PubMed33021674
UniProtP0A3U0|LTRA_LACLC Group II intron-encoded protein LtrA (Gene Name=ltrA)

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