Structure of PDB 7cow Chain C Binding Site BS01

Receptor Information
>7cow Chain C (length=107) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KAKTRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLTAEI
LELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQ
AVLLPKK
Ligand information
>7cow Chain I (length=353) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cgctgcgaaaaaaaaaacgcatcccggtgccgaggccgctcaattggtcg
tagacagctctagcaccgcttaaacgcacgtacgcgctgtctaccgcgtt
ttaaccgccactagaagcgcttactagtctccaggcacgtgtgagaccgg
cacatgaaaaaaaaaatgcatgctcgagtatgaaaaaaaaaatcgcatcc
cggtgccgaggccgctcaattggtcgtagacagctctagcaccgcttaaa
cgcacgtacgcgctgtctaccgcgttttaaccgccactagaagcgcttac
tagtctccaggcacgtgtgagaccggcacatgaaaaaaaaaacgcagcgg
tac
Receptor-Ligand Complex Structure
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PDB7cow Engineering nucleosomes for generating diverse chromatin assemblies.
Resolution2.86 Å
Binding residue
(original residue number in PDB)		R29 R42 V43 G44 K75 T76 R77 K119
Binding residue
(residue number reindexed from 1)		R17 R30 V31 G32 K63 T64 R65 K107
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0030527 structural constituent of chromatin
GO:0031492 nucleosomal DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006325 chromatin organization
GO:0008285 negative regulation of cell population proliferation
GO:0031507 heterochromatin formation
GO:0061644 protein localization to CENP-A containing chromatin
Cellular Component
GO:0000786 nucleosome
GO:0005634 nucleus
GO:0005694 chromosome
GO:0043505 CENP-A containing nucleosome
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7cow, PDBe:7cow, PDBj:7cow
PDBsum7cow
PubMed33590100
UniProtP04908|H2A1B_HUMAN Histone H2A type 1-B/E (Gene Name=H2AC4)

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