Structure of PDB 7a0r Chain C Binding Site BS01

Receptor Information

>7a0r Chain C (length=197) Species: 243230 (Deinococcus radiodurans R1 = ATCC 13939 = DSM 20539)

AQINVIGQNGGRTIELPLPEVNSGVLHEVVTWQLASRRRGTASTRTRAQV
SKTGRKMYGQKGTGNARHGDRSVPTFVGGGVAFGPKPRSYDYTLPRQVRQ
LGLAMAIASRQEGGKLVAVDGFDIADAKTKNFISWAKQNGLDGTEKVLLV
TDDENTRRAARNVSWVSVLPVAGVNVYDILRHDRLVIDAAALEIVEE

Ligand information

>7a0r Chain X (length=2730)

ggucaagauaguaaggguccacgguggaugcccuggcgcuggagccgaug
aaggacgcgauuaccugcgaaaagccccgacgagcuggagauacgcuuug
acucggggauguccgaauggggaaacccaccucguaagagguauccgcaa
ggaugggaacucagggaacugaaacaucucaguaccugaaggagaagaaa
gagaauucgauuccguuaguagcggcgagcgaacccggaucagcccaaac
cgaaacgcuugcguuucgggguuguaggaccaucaagccgaaguggcugg
aaagcuacaccucagaaggugagaguccuguaggcgaacgagccugagua
ggucguuguucgugaaacgaugacugaauccgcgcggaccaccgcgcaag
gcuaaauacucccagugaccgauagcgcauaguaccgugagggaaaggug
aaaagaaccccgggaggggagugaaagagaaccugaaaccguggacuuac
aagcagucauggcaccuuaugcguguuauggcgugccuauugaagcauga
gccggcgacuuagaccugacgugcgagcuuaaguugaaaaacggaggcgg
agcgaaagcgaguccgaauagggcggcauuaguacgucgggcuagacucg
aaaccaggugagcuaagcaugaccagguugaaacccccgugacagggggc
ggaggaccgaaccggugccugcugaaacagucucggaugaguuguguuua
ggagugaaaagcuaaccgaaccuggagauagcuaguucuccccgaaaugu
auugagguacagccucggauguugaccauguccuguagagcacucacaag
gcuaaaaccuuaugaaacuccgaaggggcacgcguuuaguccgggaguga
ggcugcgagagcuaacuuccguagccgagagggaaacaacccagaccauc
agcuaaggucccuaaaugaucgcucagugguuaaggaugugucgucgcau
agacagccaggagguuggcuuagaagcagccacccuucaaagagugcgua
auagcucacuggucgagugacgaugcgccgaaaaugaucggggcucaagu
gaucuaccgaagcuauggauucaacucgcgaagcgaguugucugguaggg
gagcguucaguccgcggagaagccauaccggaaggagugguggagccgac
ugaagugcggaugccggcaugaguaacgauaaaagaagugagaaucuucu
ucgccguaaggacaaggguuccuggggaagggucguccgcccagggaaag
ucgggaccuaaggugaggccgaacggcgcagccgauggacagcaggucaa
gauuccugcaccgaucauguggagugauggagggacgcauuacgcuaucc
aaugccaagcuauggcuaugcugguugguacgcucaagggcgaucggguc
agaaaaucuaccggucacaugccucagacguaucgggagcuuccucggaa
gcgaaguuggaaacgcgacggugccaagaaaagcuucuaaacguugaaac
augauugcccguaccgcaaaccgacacagguguccgagugucaaugcacu
aaggcgcgcgagagaacccucguuaaggaacuuugcaaucucaccccgua
acuucggaagaagggguccccacgcuucgcguggggcgcagugaauaggc
ccaggcgacuguuuaccaaaaucacagcacucugccaacacgaacagugg
acguauagggugugacgccugcccggugccggaaggucaaguggagcggu
gcaagcugcgaaaugaagccccggugaacggcggcuaagguagcgaaauu
ccuugucggguaaguuccgaccugcacgaaaggcguaacgaucugggcgc
ugucucaacgagggacucggugaaauugaauuggcuguaaagaugcggcc
uacccguagcaggacgaaaagaccccguggagcuuuacuauagucuggca
uugggauucggguuucuagaaacuuggauuucuaaccugaaaaaucacuu
ucggggaccgugcuuggcggguaguuugacuggggcggucgccucccaaa
auguaacggaggcgcccaaaggucaccucaagacgguuggaaaucgucug
uagagcgcaaagguagaagguggcuugacugcgagacugacacgucgagc
agggaggaaacucgggcuuagugaaccggugguaccguguggaagggcca
ucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccg
agaguccauaucggcggggagguuuggcaccucgaugucggcucgucgca
uccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagc
ggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccg
cuacgggcgcaggagaauugaggggaguugcuccuaguacgagaggaccg
gagugaacggaccgcuggucucccugcugucguaccaacggcacaugcag
gguagcuauguccggaacggauaaccgcugaaagcaucuaagcgggaagc
cagccccaagaugaguucucccacuguuuaucagguaagacucccggaag
accaccggguuaagaggccaggcgugcacgcauagcaauguguucagcgg
acuggugcucaucagucgaggucuugacca

<<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<....
..<<<<<<.[...((.>>>.....<<<<<<...<<.))...]..>>....
..>>>>>>...>>>....<<<....>>><<<<<....>>>>><<<<....
>>>>>>...<<<<<<.....<......>......>>>>>.>.........
<<....>>...<<<<......<<.....>>.....>>>>...<<<....<
<<<<.<<....>>.>>>>>......<<<....<<..<<<...<<<<<...
...>>>>>((......<<<.....))>>>...>>>....>>.>>>.....
<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>
>>......>>.>>>>>>.>>..............<<....>>....>>..
.......<<<<....>>>>..................>>>>>>>>>>>..
.....<<<<<<<<<<.......>>>>>>>>>>...<.<........>.>.
<<<<<<....<<<.<<<<<<<<<<..<<<...<<<....>>>...>>>..
.<<....>>...<<......>>.........>>>>>>>>>>>>>..<<.<
...<<<<<<.....<<<<<<<<<..<<<.....<<<<<......>>>>>.
.....>>>...<<<<.<.<<........>>.>>>>>....>>>>>>>>>.
..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<
<<....>>>>><<<<<<<<<...<<<<.<<<<<<...<<<...<<<.<<<
<......>>>>.>>>..>>.>...>>>>>>.>.>>>..>>>>>>>.>>..
<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.
<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<...
...<.<<<<<.<<<..<<<<.......>>>>..>>>.........<<...
...>>...>>>>>.>..>>>>>>>>>.>>..........)))......>>
>>>>.>>>...>>>>>>><..<<<<<<<<...>>>>>>>>..>....>>>
>>><.<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>
>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>
><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....(
(<<<<.<<...<<<...<<<<..>>>>...>>>...>>...<<<<<....
....>>>>>))<<<<<<<<<...<<...<<<<....<<<<..<<<..<<<
<<.<<<<.<<...[[....>>>>>><<<<<<<.<<..<<<<<<<<<<...
<<.....>>.>>>>>>....>>>>..>>>>>>>>>...<<<<<....>>>
>>....>>>>>...>>>...>>>>.........>>>>...>>......>>
>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>
..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...
.<<..>>.....>>>>><<<<<<<<...>>>>>>>>............<<
<<<<<<<..<<...........>>..<<<<<<<.....<<<.....>>>.
......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<
....>>>>>...>>...>>>>>>>>..>>>>>..........<.......
....<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..
>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>
..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<
<.<<<<<<<<<<<<<<<>>>>>>>>>>>>>>>...<<<<<<.......>.
>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<....
.......>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.
....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>
>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>
>>>.............>>>>..>>>>>>.......<<<<...<<<<<<..
.<<.......>>...>>>>>>....>>>.>.......<.<<<.<<<<<<.
.<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>
>>>..>...>>>..>....<<<<<<<....>>>.>>>>........>>>>
>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>
>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.]].>>>>>>...>>>>
>...>>>>.>>>>>....<<....<<<<<...........>>>>>....>
>..>>>>.......>>>>>>>..<<<.....>>>....<<<<<<<<<...
....>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>.
.>>>>>.>>>...>>>>....>>>>>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7a0r Ribosome-binding and anti-microbial studies of the mycinamicins, 16-membered macrolide antibiotics from Micromonospora griseorubida.
• Resolution: 3.3 Å
• Binding residue (original residue number in PDB): Q34 L35 R39 R40 T42 S44 T45 R46 Q50 S52 T54 R56 Q61 K62 G63 G65 N66 A67 R68 H69 R72 T76 F77 V78 A83 F84 P86 P88 R89 Y93 T94 P96 R97 Q98 R100 K129 T130 I134 R159 R162 N163 G174 N176 Y178
• Binding residue (residue number reindexed from 1): Q33 L34 R38 R39 T41 S43 T44 R45 Q49 S51 T53 R55 Q60 K61 G62 G64 N65 A66 R67 H68 R71 T75 F76 V77 A82 F83 P85 P87 R88 Y92 T93 P95 R96 Q97 R99 K128 T129 I133 R158 R161 N162 G173 N175 Y177

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7a0r, PDBe:7a0r, PDBj:7a0r
• PDBsum: 7a0r
• PubMed: 34417608
• UniProt: Q9RXK1|RL4_DEIRA Large ribosomal subunit protein uL4 (Gene Name=rplD)