Structure of PDB 6zx9 Chain C Binding Site BS01

Receptor Information

>6zx9 Chain C (length=257) Species: 10665,11723

NIFEMLRIDHGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIG
RNTNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRAALIN
MVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVIT
TFRTGTWDAYKNLAAAMERVPPSHRPPWHSRVVPTTMQQAQQAMWDLNEE
AEKHFSREELRGIWNDVTELPADPNWTVDQAAIACAIDYIRRTQTLLFRH
YREGCYH

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 6zx9 Chain C Residue 101

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6zx9 Structural insights into Cullin4-RING ubiquitin ligase remodelling by Vpr from simian immunodeficiency viruses.
• Resolution: 2.51973 Å
• Binding residue (original residue number in PDB): H38 H84 C89 H91
• Binding residue (residue number reindexed from 1): H204 H250 C255 H257
• Annotation score: 4

Enzymatic activity

• Enzyme Commision number: 3.2.1.17: lysozyme.

Gene Ontology

Molecular Function

• GO:0003796 lysozyme activity
• GO:0016798 hydrolase activity, acting on glycosyl bonds

Biological Process

• GO:0009253 peptidoglycan catabolic process
• GO:0016998 cell wall macromolecule catabolic process
• GO:0019058 viral life cycle
• GO:0031640 killing of cells of another organism
• GO:0042742 defense response to bacterium
• GO:0044659 viral release from host cell by cytolysis

Cellular Component

• GO:0030430 host cell cytoplasm
• GO:0042025 host cell nucleus

External links

• PDB: RCSB:6zx9, PDBe:6zx9, PDBj:6zx9
• PDBsum: 6zx9
• PubMed: 34339457
• UniProt: A4UDG5;
  P00720|ENLYS_BPT4 Endolysin (Gene Name=E)