Structure of PDB 6x2v Chain C Binding Site BS01

Receptor Information
>6x2v Chain C (length=982) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DLDIALLDQVVSTFYQGSGVQQKQAQEILTKFQDNPDAWQKADQILQFST
NPQSKFIALSILDKLITRKWKLLPNDHRIGIRNFVVGMIISMCQDDEVFK
TQKNLINKSDLTLVQILKQEWPQNWPEFIPELIGSSSSSVNVCENNMIVL
KLLSEEVFDFSAEQMTQAKALHLKNSMSKEFEQIFKLCFQVLEQGSSSSL
IVATLESLLRYLHWIPYRYIYETNILELLSTKFMTSPDTRAITLKCLTEV
SNLKQDNDLIKRQTVLFFQNTLQQIATSVMPVTADLKATYANANGNDQSF
LQDLAMFLTTYLARNRALLESDESLRELLLNAHQYLIQLSKIEERELFKT
TLDYWHNLVADLFYEPLKKHIYEEICSQLRLVIIENMVRPTIQLYKSERE
VLVYLTHLNVIDTEEIMISKLARQIDGSEWSWHNINTLSWAIGSISGTMS
EDTEKRFVVTVIKDLLGLCEQKRGKDNKAVVASDIMYVVGQYPRFLKAHW
NFLRTVILKLFEFMHETHEGVQDMACDTFIKIVQKCKYHFVIQQPRESEP
FIQTIIRDIQKTTADLQPQQVHTFYKACGIIISEERSVAERNRLLSDLMQ
LPNMAWDTIVEQSTANPTLLLDSETVKIIANIIKTNVAVCTSMGADFYPQ
LGHIYYNMLQLYRAVSSMISAQVAAEGLIATKTPKVRGLRTIKKEILKLV
ETYISKARNLDDVVKVLVEPLLNAVLEDYMNNVPDARDAEVLNCMTTVVE
KVGHMIPQGVILILQSVFECTLDMINKDFTEYPEHRVEFYKLLKVINEKS
FAAFLELPPAAFKLFVDAICWAFKHNNRDVEVNGLQIALDLVKNIERMGN
VPFANEFHKNYFFIFVSETFFVLTDSDHKSGFSKQALLLMKLISLVYDNK
ISVPLYQEAEVPQGTSNQVYLSQYLANMLSNAFPHLTSEQIASFLSALTK
QCKDLVVFKGTLRDFLVQIKEVGGDPTDYLFA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6x2v Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation.
Resolution2.822 Å
Binding residue
(original residue number in PDB)		L536 F572 T575 K579 F583
Binding residue
(residue number reindexed from 1)		L466 F502 T505 K509 F513
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005049 nuclear export signal receptor activity
GO:0005515 protein binding
GO:0017070 U6 snRNA binding
GO:0030619 U1 snRNA binding
GO:0030620 U2 snRNA binding
GO:0030621 U4 snRNA binding
GO:0030623 U5 snRNA binding
GO:0031267 small GTPase binding
GO:0061608 nuclear import signal receptor activity
Biological Process
GO:0000055 ribosomal large subunit export from nucleus
GO:0000056 ribosomal small subunit export from nucleus
GO:0006406 mRNA export from nucleus
GO:0006409 tRNA export from nucleus
GO:0006611 protein export from nucleus
GO:0006886 intracellular protein transport
GO:0015031 protein transport
GO:0034501 protein localization to kinetochore
GO:0051168 nuclear export
GO:0051170 import into nucleus
GO:0071528 tRNA re-export from nucleus
Cellular Component
GO:0000776 kinetochore
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005816 spindle pole body
GO:0048471 perinuclear region of cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6x2v, PDBe:6x2v, PDBj:6x2v
PDBsum6x2v
PubMed32520643
UniProtP30822|XPO1_YEAST Exportin-1 (Gene Name=CRM1)

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