Structure of PDB 6x2u Chain C Binding Site BS01

Receptor Information
>6x2u Chain C (length=992) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EGILDFSNDLDIALLDQVVSTFYQGSGVQQKQAQEILTKFQDNPDAWQKA
DQILQFSTNPQSKFIALSILDKLITRKWKLLPNDHRIGIRNFVVGMIISM
CQDDEVFKTQKNLINKSDLTLVQILKQEWPQNWPEFIPELIGSSSSSVNV
CENNMIVLKLLSEEVFDFSAEQMTQAKALHLKNSMSKEFEQIFKLCFQVL
EQGSSSSLIVATLESLLRYLHWIPYRYIYETNILELLSTKFMTSPDTRAI
TLKCLTEVSNLKIPQDNDLIKRQTVLFFQNTLQQIATSVMPVTADLKATY
ANANGNDQSFLQDLAMFLTTYLARNRALLESDESLRELLLNAHQYLIQLS
KIEERELFKTTLDYWHNLVADLFYEPLKKHIYEEICSQLRLVIIENMVRP
TIQLYKSEREVLVYLTHLNVIDTEEIMISKLARQIDGSEWSWHNINTLSW
AIGSISGTMSEDTEKRFVVTVIKDLLGLCEQKRGKDNKAVVASDIMYVVG
QYPRFLKAHWNFLRTVILKLFEFMHETHEGVQDMACDTFIKIVQKCKYHF
VIQQPRESEPFIQTIIRDIQKTTADLQPQQVHTFYKACGIIISEERSVAE
RNRLLSDLMQLPNMAWDTIVEQSTANPTLLLDSETVKIIANIIKTNVAVC
TSMGADFYPQLGHIYYNMLQLYRAVSSMISAQVAAEGLIATKTPKVRGLR
TIKKEILKLVETYISKARNLDDVVKVLVEPLLNAVLEDYMNNVPDARDAE
VLNCMTTVVEKVGHMIPQGVILILQSVFECTLDMINKDFTEYPEHRVEFY
KLLKVINEKSFAAFLELPPAAFKLFVDAICWAFKHNNRDVEVNGLQIALD
LVKNIERMGNVPFANEFHKNYFFIFVSETFFVLTDSDHKSGFSKQALLLM
KLISLVYDNKISVPLYQEAEVPQGTSNQVYLSQYLANMLSNAFPHLTSEQ
IASFLSALTKQCKDLVVFKGTLRDFLVQIKEVGGDPTDYLFA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6x2u Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		L536 E540 K545 K548 F565 H569 F572 T575 K579 E586
Binding residue
(residue number reindexed from 1)		L476 E480 K485 K488 F505 H509 F512 T515 K519 E526
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005049 nuclear export signal receptor activity
GO:0005515 protein binding
GO:0017070 U6 snRNA binding
GO:0030619 U1 snRNA binding
GO:0030620 U2 snRNA binding
GO:0030621 U4 snRNA binding
GO:0030623 U5 snRNA binding
GO:0031267 small GTPase binding
GO:0061608 nuclear import signal receptor activity
Biological Process
GO:0000055 ribosomal large subunit export from nucleus
GO:0000056 ribosomal small subunit export from nucleus
GO:0006406 mRNA export from nucleus
GO:0006409 tRNA export from nucleus
GO:0006611 protein export from nucleus
GO:0006886 intracellular protein transport
GO:0015031 protein transport
GO:0034501 protein localization to kinetochore
GO:0051168 nuclear export
GO:0051170 import into nucleus
GO:0071528 tRNA re-export from nucleus
Cellular Component
GO:0000776 kinetochore
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005816 spindle pole body
GO:0048471 perinuclear region of cytoplasm

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6x2u, PDBe:6x2u, PDBj:6x2u
PDBsum6x2u
PubMed32520643
UniProtP30822|XPO1_YEAST Exportin-1 (Gene Name=CRM1)

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