Structure of PDB 6wwx Chain C Binding Site BS01

Receptor Information
>6wwx Chain C (length=272) Species: 12366 (Streptococcus pyogenes phage H4489A) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TNSKITKLESSKADKSAVYSKAESKIELDKKLSLTGGIVTGQLQFKPNKS
GIKPSSSVGGAINIDMSKSEGAAMVMYTNKDTTDGPLMILRSDKDTFDQS
AQFVDYSGKTNAVNIVMRQPSAPNFSSALNITSANEGGSAMQIRGVEKAL
GTLKITHENPNVEAKYDENAAALSIDIVKKQKGGKGTAAQGIYINSTSGT
AGKMLRIRNKNEDKFYVGPDGGFHSGANSTVAGNLTVKDPTSGKHAATKD
YVDEKIAELKKLILKKLEHHHH
Ligand information
Ligand IDBDP
InChIInChI=1S/C6H10O7/c7-1-2(8)4(5(10)11)13-6(12)3(1)9/h1-4,6-9,12H,(H,10,11)/t1-,2-,3+,4-,6+/m0/s1
InChIKeyAEMOLEFTQBMNLQ-QIUUJYRFSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.0[C@@H]1([C@@H]([C@H](O[C@H]([C@@H]1O)O)C(=O)O)O)O
OpenEye OEToolkits 1.7.0C1(C(C(OC(C1O)O)C(=O)O)O)O
CACTVS 3.370O[CH]1O[CH]([CH](O)[CH](O)[CH]1O)C(O)=O
ACDLabs 12.01O=C(O)C1OC(O)C(O)C(O)C1O
CACTVS 3.370O[C@@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)C(O)=O
FormulaC6 H10 O7
Namebeta-D-glucopyranuronic acid;
beta-D-glucuronic acid;
D-glucuronic acid;
glucuronic acid
ChEMBLCHEMBL1159524
DrugBankDB03156
ZINCZINC000004097543
PDB chain6wwx Chain I Residue 2 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6wwx Crystal Structure of Streptococcal Bacteriophage Hyaluronidase: Presence of a Prokaryotic Collagen and Elucidation of Catalytic Mechanism
Resolution2.2 Å
Binding residue
(original residue number in PDB)		R311 R313
Binding residue
(residue number reindexed from 1)		R206 R208
Annotation score4
Enzymatic activity
Enzyme Commision number 3.2.1.35: hyaluronoglucosaminidase.
Gene Ontology
Molecular Function
GO:0004415 hyalurononglucosaminidase activity
Biological Process
GO:0045227 capsule polysaccharide biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6wwx, PDBe:6wwx, PDBj:6wwx
PDBsum6wwx
PubMed
UniProtP15316|HYLP1_BPH44 Hyaluronoglucosaminidase (Gene Name=HYLP1)

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