Structure of PDB 6wmp Chain C Binding Site BS01

Receptor Information
>6wmp Chain C (length=1196) Species: 376619 (Francisella tularensis subsp. holarctica LVS) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MSYSYAEKKRIRKEFGVLPHILDVPYLLSIQTESYKKFLTVDAAKGRLHS
GLEIVLKQSFPVESKNGQYELHYVDYQIGEPTFDETECQVRGATYDAPLN
VKLRLVVYNKDALPNEKIVEDIREEYVYMGDIPLMTTNGTFIINGTERVV
VSQLHRSPGAFFSKDDSEEGAFSARIIPYRGSWLDFEFDSKGIIWARIDR
KRKFCATVILKALGYTQEQILENRGRYISDTLKYDLTRNTDEALVEIYKV
LRPGDPPAAASVKALFEGLFFIESRYSLSDIGRMKLNARLGSDKVSKDIY
TLENSDIVGVIEELINIRDGKGKVDDIDHLGNRRVRSVGEMVENQFRIGL
YRVEKGIRESMSLVHKDKLMPKDIVNSKPITAAIKEFFTSGALSQFMDQD
NPLSEVTHKRRISALGPGGLSRDRAGFEVRDVHATHYGRLCPIETPEGPN
IGLINSLASYARVNDYGFLEAPYRKVVDGKVTDEIEYLSAIDEDNYVIAQ
ASTKLDENNHFVEDIIQCRSGGEAIFTESSRVQYMDVSAKQMVSAAAALI
PFLEHDDANRVLMGANMQRQAVPTLKSEKPLVGTGMEKIVARDSGNCIIA
RNVGEVAEVDSNRIVIKVDTEKSQTSNLVDIYSLTKFKRSNKNTCINQRP
IVNVGDKVEAGDILADGFATDFGELSLGHNLMVAFMPWNGYNFEDSILLS
ERIVKDDKYTSIHIEEFTCVARDTKLGPEEITADIPNVSESSLAKLDESG
IVHIGANVEAGDILVAKITPKAEQQLTPEERLLRAIFNEKASNVVDSSLR
MPSGTSGTVINVQVFENDKGGKSKRALKIEKELIDKARKDFDEEFAVIES
VVKSSIEQEVVGEKVQNAREYYEEAKIAIDAKFEAKKKSITQSNELSPGV
LKTVKVFVAIKKRIQPGDKMAGRHGNKGVVSRVLPVEDMPYMEDGTPVDV
CLNPLGIPSRMNIGQILEAHLGLASYGLGKKIEKTLEKTRKAAELRKTLE
EVYNSVGDKKVNLEALNDEEILTLCDNLKGGVPIATPVFDGAKEEDIKSL
LKIGGFATNGQMKLFDGRTGKPFDRHVTVGYMYMLKLDHLVDDKMHARST
GSYSLVTQQPLGGKAQFGGQRFGEMEVWALQAYGAAYTLREMLTVKSDDI
AGRSKMYKNIVDGKLTMNVDVPESFNVLRNEVRALGIDMDFDYSSE
Ligand information
Receptor-Ligand Complex Structure
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PDB6wmp Structural Basis for Virulence Activation of Francisella tularensis.
Resolution2.98 Å
Binding residue
(original residue number in PDB)		R148 T510 F517 G1273 K1274 R1281
Binding residue
(residue number reindexed from 1)		R148 T389 F396 G1113 K1114 R1121
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6wmp, PDBe:6wmp, PDBj:6wmp
PDBsum6wmp
PubMed33217319
UniProtQ2A1M7|RPOB_FRATH DNA-directed RNA polymerase subunit beta (Gene Name=rpoB)

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