Structure of PDB 6vzu Chain C Binding Site BS01

Receptor Information

>6vzu Chain C (length=396) Species: 10090 (Mus musculus)

KRLVINLSNCRYDSVRRAAQQYGLREAGDNDDWTLYWTDYSVSLERVMEM
KSYQKINHFPGMSEICRKDLLARNMSRMLKLFPKDFHFFPRTWCLPADWG
DLQTYSRTRKNKTYICKPDSGCQGRGIFITRSVKEIKPGEDMICQLYISK
PFIIDGFKFDLRVYVLVTSCDPLRVFVYNEGLARFATTSYSHPNLDNLDE
ICMHLTNYSINKHSSNFVQDAFSGSKRKLSTFNSYMKTHGYDVEQIWRGI
EDVIIKTLISAHPVIKHNYHTCFPSHTLNSACFEILGFDILLDRKLKPWL
LEVNHSPSFSTDSKLDKEVKDSLLYDALVLINLGNCDKKKVLEEERQRGR
EIRLEEVKGFQAMRLQKTEEYEKKNCGGFRLIYPGLNLEKYDKFFQ

Ligand information

• Ligand ID: RZV
• InChI: InChI=1S/C12H20NO9P/c1-7(14)13-9(3-5-11(17)18)23(21,22)6-8(12(19)20)2-4-10(15)16/h8-9H,2-6H2,1H3,(H,13,14)(H,15,16)(H,17,18)(H,19,20)(H,21,22)/t8-,9-/m1/s1
• InChIKey: ZYUHYZCJHIQCIO-RKDXNWHRSA-N
• SMILES:
  OpenEye OEToolkits 2.0.7: CC(=O)N[C@@H](CCC(=O)O)P(=O)(C[C@@H](CCC(=O)O)C(=O)O)O
  CACTVS 3.385: CC(=O)N[CH](CCC(O)=O)[P](O)(=O)C[CH](CCC(O)=O)C(O)=O
  CACTVS 3.385: CC(=O)N[C@@H](CCC(O)=O)[P](O)(=O)C[C@@H](CCC(O)=O)C(O)=O
  OpenEye OEToolkits 2.0.7: CC(=O)NC(CCC(=O)O)P(=O)(CC(CCC(=O)O)C(=O)O)O
• Formula: C12 H20 N O9 P
• Name: (2~{S})-2-[[[(1~{R})-1-acetamido-4-oxidanyl-4-oxidanylidene-butyl]-oxidanyl-phosphoryl]methyl]pentanedioic acid
• ZINC: ZINC000096273092
• PDB chain: 6vzu Chain C Residue 701

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6vzu Structural basis for polyglutamate chain initiation and elongation by TTLL family enzymes.
• Resolution: 1.98 Å
• Binding residue (original residue number in PDB): R148 K169 T170 L203 Y204 I205 S206 W356
• Binding residue (residue number reindexed from 1): R91 K112 T113 L146 Y147 I148 S149 W299
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 6.3.2.-

Gene Ontology

Biological Process

• GO:0036211 protein modification process

External links

• PDB: RCSB:6vzu, PDBe:6vzu, PDBj:6vzu
• PDBsum: 6vzu
• PubMed: 32747782
• UniProt: A4Q9E8|TTLL6_MOUSE Tubulin polyglutamylase TTLL6 (Gene Name=Ttll6)