Structure of PDB 6v5c Chain C Binding Site BS01

Receptor Information
>6v5c Chain C (length=217) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SVQDKKEFVINPNGKSEVCILHEYMQRVLKVRPVYNFFECENPSEPFGAS
VTIDGVTYGSGTASSKKLAKNKAARATLEILIPDFVKQSEELEYFNHISI
EDSRVYELTSKAGLLSPYQILHECLKRNHGMGDTSIKFEQKSEYVMACGK
HTVRGWCKNKRVGKQLASQKILQLLHPHVKNWGSLLRMYGREKPNLHILS
KLQEEMKRLAEEREETR
Ligand information
>6v5c Chain D (length=66) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cuuguuccacucuagcagcacguaaauauuggcaccaauauuacugugcu
gcuuuagugugacagg
..<<<<.<<<<..<<<<<<<<<..<<<<<<<<..>>>>>>>>..>>>>>>
>>>..>>>>.>>>>..
Receptor-Ligand Complex Structure
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PDB6v5c Cryo-EM Structures of Human Drosha and DGCR8 in Complex with Primary MicroRNA.
Resolution4.4 Å
Binding residue
(original residue number in PDB)		K510 C514 H517 R522 R527 F641 K667 N668
Binding residue
(residue number reindexed from 1)		K15 C19 H22 R27 R32 F138 K158 N159
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0020037 heme binding
GO:0042802 identical protein binding
Biological Process
GO:0031053 primary miRNA processing
Cellular Component
GO:0070877 microprocessor complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6v5c, PDBe:6v5c, PDBj:6v5c
PDBsum6v5c
PubMed32220646
UniProtQ8WYQ5|DGCR8_HUMAN Microprocessor complex subunit DGCR8 (Gene Name=DGCR8)

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