Structure of PDB 6uhc Chain C Binding Site BS01

Receptor Information
>6uhc Chain C (length=354) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MAYHSFLVEPISCHAWNKDRTQIAICPNNHEVHIYEKSGAKWTKVHELKE
HNGQVTGIDWAPESNRIVTCGTDRNAYVWTLKGRTWKPTLVILRINRAAR
CVRWAPNENKFAVGSGSRVISICYFEQENDWWVCKHIKKPIRSTVLSLDW
HPNNVLLAAGSCDFKCRIFSAYIKEVEERPAPTPWGSKMPFGELMFESSS
SCGWVHGVCFSASGSRVAWVSHDSTVCLADADKKMAVATLASETLPLLAL
TFITDNSLVAAGHDCFPVLFTYDAAAGMLSFGGRLDVPARERFQNLDKKA
AGLDSLHKNSVSQISVLSGGKAKCSQFCTTGMDGGMSIWDVKSLESALKD
LKIK
Ligand information
>6uhc Chain H (length=21) Species: 10090 (Mus musculus) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
GIVGALMEVMQKRSKAIEWED
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6uhc Cryo-EM structure of NPF-bound human Arp2/3 complex and activation mechanism.
Resolution3.9 Å
Binding residue
(original residue number in PDB)		R94 E126 R179 S187 M189
Binding residue
(residue number reindexed from 1)		R94 E126 R179 S187 M189
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003779 actin binding
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
GO:0044877 protein-containing complex binding
GO:0051015 actin filament binding
Biological Process
GO:0032355 response to estradiol
GO:0034314 Arp2/3 complex-mediated actin nucleation
GO:0043627 response to estrogen
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005885 Arp2/3 protein complex
GO:0005925 focal adhesion
GO:0015629 actin cytoskeleton
GO:0036284 tubulobulbar complex
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6uhc, PDBe:6uhc, PDBj:6uhc
PDBsum6uhc
PubMed32548263
UniProtO15143|ARC1B_HUMAN Actin-related protein 2/3 complex subunit 1B (Gene Name=ARPC1B)

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