Structure of PDB 6ttk Chain C Binding Site BS01
Receptor Information
>6ttk Chain C (length=284) Species:
9606
(Homo sapiens) [
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ANEVLLVVGGFGSQQSPIDVVEKYDPKTQEWSFLPSITRKRRYVASVSLH
DRIYVIGGYDGRSRLSSVECLDYTGVWYSVAPMNVRRGLAGATTLGDMIY
VSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLG
GYDGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFD
GTAHLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNS
LLSSIECYDPIIDSWEVVTSMGTQRCDAGVCVLR
Ligand information
>6ttk Chain G (length=8) Species:
9606
(Homo sapiens) [
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GPPGGPPV
Receptor-Ligand Complex Structure
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PDB
6ttk
Identification of a PGXPP degron motif in dishevelled and structural basis for its binding to the E3 ligase KLHL12.
Resolution
2.383 Å
Binding residue
(original residue number in PDB)
F289 Y321 I439 F481 H486 Y512 Y528
Binding residue
(residue number reindexed from 1)
F11 Y43 I157 F199 H204 Y230 Y246
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:6ttk
,
PDBe:6ttk
,
PDBj:6ttk
PDBsum
6ttk
PubMed
32574548
UniProt
Q53G59
|KLH12_HUMAN Kelch-like protein 12 (Gene Name=KLHL12)
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