Structure of PDB 6trw Chain C Binding Site BS01

Receptor Information
>6trw Chain C (length=838) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSD
RIYYLAMSRENTLFYSEIPKTINRAAVLMLSWKPLLDLYSREEELLRERK
RIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVET
SCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANM
EEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDES
EVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDV
IDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISP
ELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQS
HEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIK
EEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVN
PGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDP
TCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPG
KKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCH
RGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGY
LSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLG
SVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQI
YPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKV
Ligand information
Receptor-Ligand Complex Structure
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PDB6trw Aerosol-based ligand soaking of reservoir-free protein crystals.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		M76 R160 E275 E276 Y669 W754 S755 V781 W784 Y787 Y791 H865 S866 I867 R868 P870 Y876
Binding residue
(residue number reindexed from 1)		M29 R101 E216 E217 Y610 W695 S696 V722 W725 Y728 Y732 H806 S807 I808 R809 P811 Y817
Enzymatic activity
Catalytic site (original residue number in PDB) Y669 S755 Y756 D833 H865
Catalytic site (residue number reindexed from 1) Y610 S696 Y697 D774 H806
Enzyme Commision number 3.4.14.5: dipeptidyl-peptidase IV.
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0005515 protein binding
GO:0008236 serine-type peptidase activity
GO:0008239 dipeptidyl-peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0006915 apoptotic process
GO:0006955 immune response
GO:0043069 negative regulation of programmed cell death
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6trw, PDBe:6trw, PDBj:6trw
PDBsum6trw
PubMed34188616
UniProtQ6V1X1|DPP8_HUMAN Dipeptidyl peptidase 8 (Gene Name=DPP8)

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