Structure of PDB 6tgk Chain C Binding Site BS01

Receptor Information
>6tgk Chain C (length=105) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDR
APVGGLGKLKMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLK
AITYA
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain6tgk Chain C Residue 903 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6tgk Crystal structure of the catalytic C-lobe of the HECT-type ubiquitin ligase E6AP.
Resolution1.3 Å
Binding residue
(original residue number in PDB)		D776 E777
Binding residue
(residue number reindexed from 1)		D35 E36
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) H818 C820
Catalytic site (residue number reindexed from 1) H77 C79
Enzyme Commision number 2.3.2.26: HECT-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0061630 ubiquitin protein ligase activity
Biological Process
GO:0000209 protein polyubiquitination

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Molecular Function
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Biological Process
External links
PDB RCSB:6tgk, PDBe:6tgk, PDBj:6tgk
PDBsum6tgk
PubMed31994269
UniProtQ05086|UBE3A_HUMAN Ubiquitin-protein ligase E3A (Gene Name=UBE3A)

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